Evidence map›Paper›PMID 39938891›Full record

ArticleThe Journal of veterinary medical science2025

Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice.

Ayano Yoshimoto, Sarika Nunobiki, Makiko Ito, Sakura Yonoichi, Yukako Hara, Yuya Ishida, Youhei Mantani, Toshifumi Yokoyama, Tetsushi Hirano, Yoshinori Ikenaka and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ayano YoshimotoLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Sarika NunobikiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Makiko ItoLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Sakura YonoichiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Yukako HaraLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Yuya IshidaLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Youhei MantaniLaboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Toshifumi YokoyamaLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Tetsushi HiranoFaculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Yoshinori IkenakaLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University, Hokkaido, Japan.
Nobuhiko HoshiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. We orally administered FPN (0.43 mg/kg) to 4-week-old male mice for 6 wk and assessed their behavior and blood characteristics. Compared with the control group, the FPN-treated group presented reduced weight gain but upward trends in locomotor activity and blood histamine levels. Fipronil sulfone (FPNS) was detected in all individuals, whereas FPN was not detected in any individual. The present study shows for the first time that subchronic exposure to low-dose FPN in mice led to FPNS conversion in the body, affecting weight gain and behavior.

Indexed as

InsecticidesPyrazolesAnimalsBehavior, AnimalDose-Response Relationship, DrugHistamineMaleMiceMotor ActivityWeight Gainfipronilfipronil sulfoneHistamineInsecticidesPyrazolesbehavioral testfipronilgamma-aminobutyric acid (GABA)insecticidelocomotor activity

Identifiers

PMID39938891
PMCPMC11964855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.