Evidence map›Paper›PMID 39938884›Full record

ReviewPhysiological reviews2025

Physiologic mechanisms underlying polycystic kidney disease.

Alessandra Boletta, Michael J Caplan

Abstract readReview
In one paragraph

Review in Physiological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Polyphenols and ADPKD: A Further Aid from Nature?Life (Basel, Switzerland) · 2026
    Review
  10. The Role of Mitochondria in Polycystic Kidney Disease.International journal of molecular sciences · 2026
    Review
  11. Polycystin-1 Controls Cell Cycle Kinetics, Cell Cycle Exit, and Differentiation of Neural Progenitor Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  12. Article
  13. Article
  14. AbioRxiv : the preprint server for biology · 2026
    Article
  15. Case Report: Functional validation of aFrontiers in genetics · 2026
    Article
  16. Models of Cellular Mechanosensation.Results and problems in cell differentiation · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alessandra BolettaIRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-4704-4006
Michael J CaplanDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0001-5768-4405

Funding

In vivo Pathway Discovery in Autosomal Dominant Polycystic Kidney DiseaseRC2DK120534 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J., SHULMAN, GERALD I · 2019 to 2023
$6.6M
Polycystin-1 C terminal tail cleavage: Mechanisms and meaningR01DK139319 · NIDDK · YALE UNIVERSITY · PI Michael J. Caplan · 2025 to 2026
$1.3M
Italian Ministry of Health RF-2016-02361267Italian Ministry of Health RF-2018-12368254NIDDK NIH HHS R01 DK139319NIDDK NIH HHS RC2 DK120534PKD Foundation (PKDF) 218G18PKD Foundation (PKDF) 905682U.S. Department of Defense (DOD) CDMRP level 2U.S. Department of Defense (DOD) PR191158
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) encompasses a class of disorders presenting with bilateral cyst formation in the kidney. PKD can be inherited as a dominant (ADPKD) or a recessive (ARPKD) trait, due to mutations into multiple genes, the most frequent being

Indexed as

KidneyPolycystic Kidney DiseasesAnimalsCiliaHumansMutationTRPP Cation ChannelsTRPP Cation Channelscystkidneypolycystic kidney diseasepolycystinsignaling

Identifiers

PMID39938884
PMCPMC12174308

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.