A conceptual framework for modeling a latching mechanism for cell cycle regulation.

Punit Gandhi, Yangyang Wang

Abstract read

In one paragraph

Article in Mathematical biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Punit GandhiDepartment of Mathematics and Applied Mathematics, Virginia Commonwealth University, Richmond, 23226, VA, USA. Electronic address: gandhipr@vcu.edu.

Yangyang WangDepartment of Mathematics, Brandeis University, Waltham, 02453, MA, USA.

Funding

CRCNS: Evidence-based modeling of neuromodulatory action on network propertiesR01DA057767 · NIDA · UNIVERSITY OF IOWA · PI Yangyang Wang · 2022 to 2026

$1.8M

NIDA NIH HHS R01 DA057767

6 · The paper itself

Abstract

Two identical van der Pol oscillators with mutual inhibition are considered as a conceptual framework for modeling a latching mechanism for cell cycle regulation. In particular, the oscillators are biased to a latched state in which there is a globally attracting steady-state equilibrium without coupling. The inhibitory coupling induces stable alternating large-amplitude oscillations that model the normal cell cycle. A homoclinic bifurcation within the model is found to be responsible for the transition from normal cell cycling to endocycles in which only one of the two oscillators undergoes large-amplitude oscillations.

Indexed as

Cell CycleModels, BiologicalBiological ClocksHumansBifurcationCell cycle regulationCoupled oscillatorsHomoclinic bifurcationSymmetry breaking

Identifiers

PMID39938742

DOI10.1016/j.mbs.2025.109396

PMCPMC13043200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.