Evidence map›Paper›PMID 39938680›Full record

ReviewCurrent opinion in insect science2025

Influence of blood feeding and infection on arthropod hemocytes.

George-Rafael Samantsidis, Shahid Karim, Ryan C Smith

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George-Rafael SamantsidisDepartment of Entomology, Cornell University, Ithaca, NY, USA.
Shahid KarimSchool of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS, USA.
Ryan C SmithDepartment of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, IA, USA. Electronic address: smithr@iastate.edu.

Funding

Development of genetic tools for the study of mosquito hemocytesR21AI166857 · NIAID · IOWA STATE UNIVERSITY · PI SMITH, RYAN C. · 2021 to 2022
$421k
The Role of Hemocytes in tick Rickettsia parkeri infectionR21AI175885 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI KARIM, SHAHID · 2024 to 2025
$407k
NIAID NIH HHS R21 AI166857NIAID NIH HHS R21 AI175885
6 · The paper itself

Abstract

Blood feeding provides essential nutrients for development and reproduction in hematophagous arthropods yet also initiates significant other physiological alterations in immune function. Immune cells, or hemocytes, are integral components of the arthropod innate immune system with notable roles in defining vector competence. Evidence suggests that both blood feeding and infection drive substantial changes in hemocyte phenotypes, including proliferation, immune activation, and differentiation, which directly and indirectly influence pathogen infection outcomes. These dynamics have fueled extensive research into hemocyte biology in recent years, which aided by emerging single-cell technologies and methods of phagocyte depletion, have provided novel molecular insights into hemocyte populations and additional support for their important contributions to parasite, virus, and bacterial infections. Despite this progress, many aspects of arthropod immune cell biology remain unclear. Focusing on mosquitoes and ticks as two of the most prominent and well-studied arthropod vectors, this review summarizes the effects of blood feeding and infection on mosquito and tick hemocytes, highlighting hemocyte classifications, and the known mechanisms by which hemocytes can have positive or negative impacts on vector-borne pathogen infection.

Indexed as

CulicidaeHemocytesTicksAnimalsFeeding Behavior

Identifiers

PMID39938680
PMCPMC12501986

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.