Evidence map›Paper›PMID 39938569›Full record

ArticleNature2025

σ-Bond insertion reactions of two strained diradicaloids.

Arismel Tena Meza, Christina A Rivera, Huiling Shao, Andrew V Kelleghan, K N Houk, Neil K Garg

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Rule-breaking in chemical synthesis.Science advances · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arismel Tena MezaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Christina A Rivera *Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Huiling Shao *Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8007-6408
Andrew V KelleghanDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9774-2873
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. houk@chem.ucla.edu.ORCID http://orcid.org/0000-0002-8387-5261
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. neilgarg@chem.ucla.edu.ORCID http://orcid.org/0000-0002-7793-2629

Funding

Exploiting Unconventional Building Blocks in Chemical SynthesisR35GM139593 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Neil K. Garg · 2021 to 2026
$4.0M
NMR Console and Prodigy CryoProbeS10OD028644 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K · 2021 to 2021
$600k
Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical ResearchS10RR025631 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2009 to 2009
$328k
Enantioselective Reactions with Amide Electrophiles Utilizing Transition-Metal CatalysisF31GM149161 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TENA-MEZA, ARISMEL · 2023 to 2025
$86k
NCRR NIH HHS S10 RR025631NIGMS NIH HHS F31 GM149161NIGMS NIH HHS R35 GM139593NIH HHS S10 OD028644
6 · The paper itself

Abstract

The development of new synthetic methodologies is instrumental for enabling the discovery of new medicines. The methods that provide efficient access to structural alternatives for aromatic compounds (that is, saturated arene bioisosteres) have become highly coveted

Identifiers

PMID39938569
PMCPMC12457010

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.