SynthesisDementia and geriatric cognitive disorders2025
Structural Neuroimaging Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease: A Systematic Literature Review.
Synthesis in Dementia and geriatric cognitive disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Olfactory Bulb and Gyrus Rectus Volumes in Alzheimer's Disease: Associations with Eating Disturbances.Medicina (Kaunas, Lithuania) · 2026Article
- Prediction of Antipsychotic Drug Doses for BPSD in Alzheimer's Disease Using Deep Learning Techniques.Diagnostics (Basel, Switzerland) · 2026Article
- Plasma neurofilament light chain and regional brain atrophy mediate the association of neuropsychiatric symptoms with cognition in Alzheimer's disease: evidence from two population-based studies.Psychological medicine · 2026Article
- Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Neuropsychiatric symptoms in mild cognitive impairment and early Alzheimer's disease: Clinical pattern and diagnostic implications.AIMS neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionNeuropsychiatric symptoms (NPS) such as increased apathy, affective symptoms, psychosis and hyperactivity are common in Alzheimer's disease (AD) and are associated with increased disease severity and caregiver burden. In contrast to well-characterized associations between AD-related cognitive deficits and focal neuropathology (e.g., memory and hippocampal atrophy), fewer studies have focused on associations between NPS-brain associations in AD. Furthermore, studies focusing on magnetic resonance imaging measures of gray matter (GM) abnormalities associated with NPS in AD have not been systematically reviewed.
methodsTo address this gap, a systematic literature review was undertaken to identify articles that assessed structural brain differences associated with NPS in AD. This review identified 29 such articles that tested associations between NPS and gray matter loss (GML: reduced GM density, reduced GM volume, decreased cortical thickness, etc.).
resultsAcross all NPS, most symptoms were associated with GML in the prefrontal cortex and medial temporal lobe, highlighting key limbic/limbic adjacent structures including orbitofrontal cortex and parahippocampal regions. Other regions exhibiting associations included the superior and middle temporal gyri as well as anterior and posterior cingulate cortex.
conclusionUnderstanding how GM changes in the brain relate to NPS in AD may not only improve our understanding of NPS and AD but may also provide help identify homologies/correspondence with brain changes in psychiatric diseases.
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Registered trials
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