ArticleAnaesthesia2025
Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction.
Article in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Mechanical Power and Mortality in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis.Critical care medicine · 2026Pooled it
- Effects of PERMISSive lung-protective ventilation on outcome in critically ill, invasively ventilated patients (PERMISS): protocol for a feasibility and safety randomised clinical trial.BMJ open respiratory research · 2026Article
- Assessment of mortality risk by respiratory rate-specific quartiles in mechanically ventilated patients with acute respiratory distress syndrome in Mexico.Internal and emergency medicine · 2026Observational
- Emerging trends and hotspots in lung-protective ventilation from 2006 to 2025: a bibliometric analysis.Journal of thoracic disease · 2026Article
- Integrating ultra-prolonged prone ventilation with mechanical power monitoring in refractory acute respiratory distress syndrome (ARDS): a case report.Frontiers in medicine · 2026Article
- Effects of increasing respiratory rate on ventilatory efficiency and mechanical costs during low-tidal-volume ventilation: a prospective physiological pilot study.Annals of intensive care · 2026Article
- Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study.Anaesthesia · 2025Article
- Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients.Intensive care medicine experimental · 2025Article
- Effects of secular changes in tidal volume and respiratory rate on the mechanical power of ventilation: a retrospective single-center study of invasively ventilated patients.Critical care science · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
introductionHigh mechanical power is associated with mortality in patients who are critically ill and require invasive ventilation. It remains uncertain which components of mechanical power - volume, pressure or rate - increase mechanical power the most.
methodsWe conducted a post hoc analysis of a database containing individual patient data from three randomised clinical trials of ventilation in patients without acute respiratory distress syndrome. The primary endpoint was mechanical power. We used linear regression; double stratification to create subgroups of participants; and mediation analysis to assess the impact of changes in volumes, pressures and rates on mechanical power.
resultsA total of 1732 patients were included and analysed. The median (IQR [range]) mechanical power was 12.3 (9.3-17.1 [3.7-50.1]) J.min DISCUSSION: In this cohort of patients without acute respiratory distress syndrome, pressure and respiratory rate were the most important determinants of mechanical power. The respiratory rate may be the most attractive ventilator setting to adjust when targeting a lower mechanical power.
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