Evidence map›Paper›PMID 39938058›Full record

ArticleOcular immunology and inflammation2025

Incidence and Outcome of Cataract in Eyes with Scleritis and Episcleritis.

Michelle J Sun, Bernard A Rosner, Craig W Newcomb, Kurt A Dreger, Pichaporn Artornsombudh, Srishti Kothari, Abhishek R Payal, Siddharth S Pujari, Grace A Levy-Clarke, H Nida Sen and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular immunology and inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Update on Therapy for Non-Infectious Scleritis.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Michelle J SunKellogg Eye Center, University of Michigan, Ann Arbor, Massachusetts, USA.
Bernard A RosnerChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Craig W NewcombCenter for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kurt A DregerDepartment of Population, Family, and Reproductive Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Pichaporn ArtornsombudhDepartment of Ophthalmology, Somdech Phra Pinklao Hospital, Royal Thai Navy, Bangkok, Thailand.
Srishti KothariScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abhishek R PayalMahatme Eye Bank Eye Hospital, Nagpur, India.
Siddharth S PujariSiddharth Netralaya Superspecialty Eye Hospital, Belgaum, India.
Grace A Levy-ClarkeDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA.
H Nida SenDepartment of Ophthalmology, George Washington University, Washington, District of Columbia, USA.
Eric B SuhlerDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Jennifer E ThorneDepartment of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nirali P BhattScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
C Stephen FosterMassachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, USA.ORCID 0000-0002-6612-5653
Douglas A JabsDepartment of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
James T RosenbaumDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Jeanine M BuchanichCenter for Occupational Biostatistics and Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Sylvia L GrothVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gui-Shuang YingScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sapna S GangaputraVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John H KempenKellogg Eye Center, University of Michigan, Ann Arbor, Massachusetts, USA.ORCID 0000-0002-2967-4792

Funding

Long-term Follow-up of the Systemic Immunosuppressive Therapy for Eye Diseases CohortR01EY014943 · NEI · UNIVERSITY OF PENNSYLVANIA · PI KEMPEN, JOHN H · 2004 to 2025
$8.1M
Use of Correlated Data Methods in OphthalmologyR01EY022445 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2013 to 2025
$4.6M
Incidence of remission and of cataract in ocular inflammatory diseasesR21EY026717 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI KEMPEN, JOHN H · 2017 to 2018
$495k
Outcomes of uveitic cataract and uveitic glaucoma surgeryR21EY032592 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GANGAPUTRA, SAPNA S · 2021 to 2022
$488k
Complications of Immunosupression for Eye DiseasesR56EY014943 · NEI · UNIVERSITY OF PENNSYLVANIA · PI KEMPEN, JOHN H · 2009 to 2009
$159k
NEI NIH HHS R01 EY014943NEI NIH HHS R01 EY022445NEI NIH HHS R21 EY026717NEI NIH HHS R21 EY032592NEI NIH HHS R56 EY014943
6 · The paper itself

Abstract

purposeTo estimate the incidence and predictive factors for cataract in eyes with episcleritis and scleritis, and to evaluate the outcome of cataract surgery in those eyes.

designRetrospective cohort study at uveitis subspecialty centers.

methodsOne thousand three hundred eighty-four eyes with non-infectious scleritis and episcleritis at risk of cataract were included. Predictive factors for cataract development were assessed by multivariable Cox regression. The main outcomes were development of cataract, defined as the first reduction of presenting visual acuity <20/40 attributed to cataract or else occurrence of cataract surgery itself. A second cohort of eyes with episcleritis and scleritis that underwent cataract surgery was evaluated for postoperative outcomes. Logistic regression was utilized to assess variables associated with visual acuity 20/40 or better one year after cataract surgery.

resultsSeventy-six eyes developed cataract (incidence = 0.025/eye-year, 95% confidence interval: 0.019-0.031). Age ≥65 years, elevated intraocular pressure ≥30 mmHg, use of oral corticosteroids at the preceding visit, and anterior chamber inflammatory activity were associated with increased cataract incidence. Race/ethnicity, type of scleritis, and bilaterality were unassociated with cataract risk after adjustment. Among 79 cataractous eyes that underwent cataract surgery, median presenting visual acuity improved by 6 ETDRS lines. Pre-operative factors including duration of inflammation, immunotherapy use, and corticosteroid use were not significantly associated with odds of post-operative visual acuity 20/40 or better.

conclusionsUnder subspecialty management, the incidence of cataract was low in eyes with episcleritis and scleritis. Cataract surgery was associated with large and sustained improvements in visual acuity.

Indexed as

CataractCataract ExtractionScleritisAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsVisual AcuitycataractepiscleritisScleritissurgeryvisual outcome

Identifiers

PMID39938058
PMCPMC12339752

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