Evidence map›Paper›PMID 39937900›Full record

ArticleScience advances2025

Diabetes potentiates the emergence and expansion of antibiotic resistance.

John C Shook, Christopher J Genito, Benjamin P Darwitz, Kaleb J Tyson, Amanda Z Velez, Sophia K Bridwell, Joshua B Parsons, Sarah E Rowe, Christopher W Marshall, Brian P Conlon and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Journal of bacteriology · 2025
    Article
  13. Elevated glucose increasesInfection and immunity · 2025
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John C ShookDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6949-8634
Christopher J GenitoDepartment of Biomedical Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9044-964X
Benjamin P DarwitzDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0936-384X
Kaleb J TysonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0002-7415-2405
Amanda Z VelezDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sophia K BridwellDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA.ORCID 0009-0009-6055-5175
Joshua B ParsonsDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sarah E RoweDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8955-359X
Christopher W MarshallDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA.ORCID 0000-0001-6669-3231
Brian P ConlonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2155-8375
Lance R ThurlowDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-1839-2922

Funding

Diabetes and Antibiotic Treatment FailureR01AI173004 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian Patrick Conlon, Lance R. Thurlow · 2023 to 2026
$2.8M
NIAID NIH HHS R01 AI173004
6 · The paper itself

Abstract

Individuals with diabetes mellitus frequently develop severe skin and soft tissue infections (SSTIs) that are recalcitrant to antibiotic treatment. We examined how diabetes affects the emergence of antibiotic resistance in a

Indexed as

Diabetes Mellitus, ExperimentalDrug Resistance, BacterialStaphylococcal InfectionsStaphylococcus aureusAnimalsAnti-Bacterial AgentsMiceMicrobial Sensitivity TestsAnti-Bacterial Agents

Identifiers

PMID39937900
PMCPMC11817934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.