Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Lauren N Rust *Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-8585-466X
Jochen M Wettengel *Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-4101-9280
Sreya BiswasDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Junghyun RyuDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-8064-5762
Nadine PiekarskiDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0009-0000-8162-5018
Sofiya YusovaDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Savannah S LutzDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0009-0001-5779-3609
Spandana NaldigaDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Brayden J HinrichsDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Michelle N SullivanDivision of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.
Jamie O LoDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-1934-1935
Ulrike ProtzerInstitute of Virology, Technical University of Munich/Helmholtz Munich, Munich 81675, Germany.ORCID 0000-0002-9421-1911
Jeremy V SmedleyDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0003-3369-4662
Jonah B SachaDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-7633-3122
Carol B HannaDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-2790-3555
Benjamin N BimberDivision of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-8092-3080
Jon D HenneboldDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0002-6760-3733
Benjamin J BurwitzDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006.ORCID 0000-0001-7767-022X
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
A Rhesus Macaque Model of HIV and HBV co-infectionR01AI157612 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI BURWITZ, BENJAMIN J · 2021 to 2025
$3.8M
Impact of maternal marijuana use on epigenetic regulation of offspring neurodevelopmentDP1DA056493 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jamie Lo · 2022 to 2026
$2.6M
Creation of a chronic HBV infection model in rhesus macaquesR21AI133632 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI BURWITZ, BENJAMIN J · 2018 to 2019
Hepatitis B virus (HBV) poses a significant global health challenge, necessitating the urgent development of curative therapeutics. However, this progress is impeded by the lack of robust, immunocompetent preclinical animal models due to HBV's strict species specificity. We previously showed that vector-mediated expression of the HBV entry receptor, human sodium-taurocholate cotransporting polypeptide (hNTCP), renders macaques fully susceptible to HBV infection. In this study, we have generated transgenic macaques expressing hNTCP, marking the creation of the first transgenic nonhuman primate model for infectious disease research. We used PiggyBac (PB) transposon technology to insert a liver-specific hNTCP expression cassette into rhesus macaque zygotes and transferred the resulting embryos into surrogate females, resulting in two healthy transgenic offspring. In both animals, hNTCP is highly and selectively expressed in the liver. Most importantly, we show that isolated hepatocytes from these monkeys are susceptible to HBV infection. These findings lay the foundation for the development of a nonhuman primate HBV model, facilitating the advancement and validation of curative HBV therapies.
Indexed as
Hepatitis BHepatitis B virusHepatocytesLiverOrganic Anion Transporters, Sodium-DependentSymportersAnimalsAnimals, Genetically ModifiedDisease Models, AnimalFemaleHumansMacaca mulattaOrganic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportershepatitis Bnonhuman primatetransgenictranslational model
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Liver-specific transgenic expression of human NTCP in rhesus macaques confers HBV susceptibility on primary hepatocytes. · full record | OpenQuestion