Evidence map›Paper›PMID 39937792›Full record

ArticlePloS one2025

LncRNA UCA1 regulates immune micro-environment in cisplatin-induced AKI by miRNA-4498/AKT3 pathway.

Peng Hongjun, Lydia Mukanhaire, Liu Zhen, Wang Ting, Li Hongye, Zhang Xiaotian, Liu Guangling, Ren Xianguo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng HongjunDepartment of Pediatrics, Nanjing Drum Tower Hospital, Affiliated hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Lydia MukanhaireJiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0002-9775-3257
Liu ZhenDepartment of Pediatrics, Nanjing Drum Tower Hospital, Affiliated hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Wang TingDepartment of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Li HongyeDepartment of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang XiaotianDepartment of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Liu GuanglingDepartment of Pediatrics, Nanjing Drum Tower Hospital, Affiliated hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Ren XianguoDepartment of Pediatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0009-0008-1654-6880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies highlight the significance of long non-coding RNAs (lncRNAs) in the biological process of acute kidney injury (AKI). This study investigates the role and the mechanism of lncRNA UCA1 in cisplatin-induced AKI. Real-time quantitative PCR was used to measure lncRNA UCA1 expression in cisplatin-induced AKI mouse model, showing that lncRNA UCA1 was overexpressed. Knockdown of lncRNA UCA1 by shRNA significantly reduced inflammation caused by cisplatin treatment. A co-culture system demonstrated that lncRNA UCA1 upregulation in T cells induced apoptosis of tubular epithelial cells (TECs). A dual-luciferase reporter assay confirmed that lncRNA UCA1 acts as a miR-4498 sponge, binding to the 3'UTR of AKT3. Flow cytometry and ELISA results showed that reduced inflammation effect induced by lncRNA UCA1 knockdown was reversed by miR-4498 inhibition or AKT3 overexpression. Our findings suggest that lncRNA UCA1 functions as a miR-4498 sponge, upregulating AKT3 expression, and promoting inflammation in cisplatin-induced AKI.

Indexed as

Acute Kidney InjuryCisplatinMicroRNAsProto-Oncogene Proteins c-aktRNA, Long NoncodingAnimalsApoptosisDisease Models, AnimalEpithelial CellsHumansMaleMiceMice, Inbred C57BLSignal TransductionAkt3 protein, mouseCisplatinMicroRNAsProto-Oncogene Proteins c-aktRNA, Long Noncoding

Identifiers

PMID39937792
PMCPMC11819503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.