Evidence map›Paper›PMID 39937677›Full record

ArticleMolecular biology of the cell2025

LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase.

Baraj Doray, Benjamin C Jennings, Xi Yang, Lin Liu, Varsha Venkatarangan, Stuart Kornfeld, Ming Li

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Baraj DorayDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-3347-5013
Benjamin C JenningsDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Xi YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Lin LiuM6P Therapeutics, St. Louis, MO 63108.
Varsha VenkataranganDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Stuart KornfeldDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Ming LiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

Funding

Structure, Biosynthesis & Function of GlycoproteinsR01CA008759 · NCI · WASHINGTON UNIVERSITY · PI KORNFELD, STUART A · 1985 to 2023
$3.5M
Characterization of TMEM251 that causes a new type of severe lysosome storage diseaseR01HD109346 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ming Li · 2022 to 2026
$2.1M
NCI NIH HHS R01 CA008759NICHD NIH HHS R01 HD109346
6 · The paper itself

Abstract

LYSET is a recently identified Golgi transmembrane (TM) protein, and inactivating mutations in the

Indexed as

Membrane ProteinsTransferases (Other Substituted Phosphate Groups)Golgi ApparatusHEK293 CellsHumansLysosomesMucolipidosesMutationProtein Domainsalpha-beta GlcNAc-1-phosphotransferase, humanMembrane ProteinsTransferases (Other Substituted Phosphate Groups)

Identifiers

PMID39937677
PMCPMC12005095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.