Evidence map›Paper›PMID 39937651›Full record

ReviewCardiovascular research2025

Immune cells and arrhythmias.

Joshua A Keefe, Jian Wang, Jiangping Song, Li Ni, Xander H T Wehrens

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Neuroimmune interactions in cardiovascular homeostasis and disease.American journal of physiology. Cell physiology · 2026
    Review
  3. Single-Nucleus RNA Sequencing Reveals SPP1Journal of cardiovascular development and disease · 2026
    Article
  4. Review
  5. A 2025 Literature Review on Arrhythmias: Returning the Focus to Basic Science.The Journal of innovations in cardiac rhythm management · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua A KeefeCardiovascular Research Institute, Baylor College of Medicine, BCM335, One Baylor Plaza, Houston, TX 77030, USA.
Jian WangDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, #1095 Jiefang Avenue, Wuhan 430030, China.
Jiangping SongBeijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, National Centre for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing 100037, China.ORCID 0000-0002-9488-7823
Li NiDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, #1095 Jiefang Avenue, Wuhan 430030, China.ORCID 0000-0002-6841-4379
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, BCM335, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0001-5044-672X

Funding

Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Mechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA, WEHRENS, XANDER H.T. · 2019 to 2022
$2.0M
Role of inflammation in postoperative atrial fibrillationR01HL180477 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.5M
Cardiomyocyte-fibroblast signaling in atrial fibrillationR01HL174510 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.3M
Macrophage-mediated interleukin-6 signaling drives ryanodine receptor 2 calcium leak in postoperative atrial fibrillationF30HL172431 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KEEFE, JOSHUA ANTHONY · 2024 to 2025
$99k
Baylor College of Medicine Medical Scientist Training ProgramNational Natural Science Foundation of China 82070354NHLBI NIH HHS F30 HL172431NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL147108NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL174510NHLBI NIH HHS R01 HL180477NIH HHS R01-HL147108Program for Huazhong University of Science and Technology Academic Frontier Youth Team 2019QYTD08Robert and Janice McNair Foundation MD/PhD Scholars Program
6 · The paper itself

Abstract

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression. In this review, we provide a comprehensive summary and expert commentary on the role of each immune cell subtype in the pathogenesis of atrial and ventricular arrhythmias.

Indexed as

Arrhythmias, CardiacHeart Conduction SystemHeart RateMyocardiumAction PotentialsAnimalsHumansSignal TransductionAtrial fibrillationCalcium handlingCardiac arrhythmiasImmune cellsMacrophages

Identifiers

PMID39937651
PMCPMC12038251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.