ArticleCell reports2025
Higher-order thalamic input to cortex selectively conveys state information.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026Review
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
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Abstract
Communication among neocortical areas is largely thought to be mediated by long-range synaptic interactions between cortical neurons, with the thalamus providing only an initial relay of information from the sensory periphery. Higher-order thalamic nuclei receive strong synaptic inputs from the cortex and send robust projections back to other cortical areas, providing a distinct and potentially critical route for corticocortical communication. However, the relative contributions of corticocortical and thalamocortical inputs to higher-order cortical function remain unclear. Using imaging of neurons and axon terminals in combination with optogenetic manipulations, we find that the higher-order visual thalamus of mice has a unique impact on the posterior medial visual cortex (PM). Whereas corticocortical projections from lower cortical areas convey robust visual information to PM, higher-order thalamocortical projections convey information about global arousal state. Together, these findings suggest a key role for the higher-order thalamus in providing contextual signals that may flexibly modulate cortical sensory processing.
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