ArticleCell reports2025
GABAergic neurons in the ventral tegmental area represent and regulate force vectors.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Article
- A dual-color miniature endoscope for calcium imaging in behaving mice.bioRxiv : the preprint server for biology · 2026Article
- The Role of the Ventral Tegmental Area in Reward and Addiction: A Comprehensive Review.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning.Nature communications · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- Flexible updating of reward and punishment contingencies by VTA GABA neurons.Current biology : CB · 2025Article
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Abstract
The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward prediction signal, which is used in computing a reward prediction error. In this study, by using in vivo electrophysiology and continuous quantification of force exertion in head-fixed mice, we identify distinct populations of VTA GABA neurons that exhibit precise force tuning independently of learning, reward prediction, and outcome valence. Their activity usually precedes force exertion, and selective optogenetic manipulations of these neurons systematically modulate force exertion without influencing reward prediction. Together, these findings show that VTA GABA neurons can continuously regulate force vectors during motivated behavior.
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