Evidence map›Paper›PMID 39937635›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation.

Styvalizh Uribe, Eyar Shany, Yi Zhang, Amy D Wu, William Dan, Jose F Perez-Zoghbi, Charles W Emala, Peter D Yim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Styvalizh UribeDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.ORCID 0009-0005-2238-1814
Eyar ShanyDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.
Yi ZhangDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.
Amy D WuDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.ORCID 0000-0003-4983-2724
William DanDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.ORCID 0000-0002-9154-8391
Jose F Perez-ZoghbiDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.ORCID 0000-0002-7554-6468
Charles W EmalaDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.
Peter D YimDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States.ORCID 0000-0003-1670-7599

Funding

Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle RelaxationK08HL150314 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YIM, PETER D · 2021 to 2025
$827k
Mentored Clinical Scientist Research Career Development Award (PA-20-203) K08HL150314NHLBI NIH HHS K08 HL150314
6 · The paper itself

Abstract

Recent studies have linked deficiencies in β-carotene ingestion and its metabolites with an increased risk and severity of asthma exacerbations. We demonstrate that β-ionone, a β-carotene metabolite, dose-dependently relaxes upper and lower airways in vitro using wire myography of tracheal rings and phase-contrast microscopy of precision-cut lung slices (PCLSs). We demonstrate that β-ionone-induced relaxation is mediated through extraocular opsin-3 (OPN3) receptor activation via pharmacological competitive inhibition with chromophore 9-

Indexed as

Muscle RelaxationMuscle, SmoothNorisoprenoidsRod OpsinsAnimalsAsthmaMaleMiceMice, Inbred C57BLMice, KnockoutTracheabeta-iononeNorisoprenoidsRod Opsinsairway smooth musclenutritionopsin-3β-caroteneβ-ionone

Identifiers

PMID39937635
PMCPMC12720294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.