Evidence map›Paper›PMID 39937529›Full record

ArticleJournal of medicinal chemistry2025

A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7.

Silas L Wurnig, Max E Huber, Corinna Weiler, Hanna Baltrukevich, Nicole Merten, Isabel Stötzel, Teresa Steffen, Yinshui Chang, René H L Klammer, Dirk Baumjohann and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Silas L WurnigDepartment of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
Max E HuberDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, Erlangen 91058, Germany.ORCID 0000-0003-3042-0463
Corinna WeilerMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn 53115, Germany.
Hanna BaltrukevichDepartment of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg 35037, Germany.
Nicole MertenMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn 53115, Germany.ORCID 0000-0002-8487-6805
Isabel StötzelLife and Medical Sciences (LIMES) Institute, Immune and Tumor Biology, University of Bonn, Bonn 53115, Germany.
Teresa SteffenMedical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.ORCID 0009-0009-3311-5051
Yinshui ChangMedical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
René H L KlammerDepartment of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
Dirk BaumjohannMedical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
Eva KiermaierLife and Medical Sciences (LIMES) Institute, Immune and Tumor Biology, University of Bonn, Bonn 53115, Germany.
Peter KolbDepartment of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg 35037, Germany.ORCID 0000-0003-4089-614X
Evi KostenisMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Bonn 53115, Germany.ORCID 0000-0001-8284-5514
Matthias SchiedelDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, Erlangen 91058, Germany.ORCID 0000-0001-7365-3617
Finn K HansenDepartment of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.ORCID 0000-0001-9765-5975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in drug discovery. Here, we report the development of the fluorescent ligand Mz437 (

Indexed as

Allosteric SiteFluorescent DyesReceptors, CCR7AnimalsDrug DiscoveryHumansLigandsStructure-Activity RelationshipCCR7 protein, humanFluorescent DyesLigandsReceptors, CCR7

Identifiers

PMID39937529
PMCPMC11873976

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.