Evidence map›Paper›PMID 39937481›Full record

ArticleJAMA network open2025

Attention-Deficit/Hyperactivity Disorder in Medicaid-Enrolled Autistic Adults.

Benjamin E Yerys, Sha Tao, Lindsay Shea, Gregory L Wallace

Abstract read
In one paragraph

Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin E YerysCenter for Autism Research and Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Sha TaoA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.
Lindsay SheaA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.
Gregory L WallaceDepartment of Speech, Language, and Hearing Sciences, The George Washington University, Washington, DC.

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Strategies to Facilitate Early Detection of Autism in Primary CareP50HD111142 · NICHD · DREXEL UNIVERSITY · PI Diana L Robins, Diana Schendel · 2022 to 2026
$12.4M
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
A longitudinal study identifying psychological and service delivery targets to improve daily living skills and quality of life outcomes among transition-age autistic youthR01MH133838 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LAUREN KENWORTHY, BENJAMIN YERYS · 2023 to 2026
$3.2M
Identifying Co-Occurrence and Service Use Profiles of Alzheimer's Disease and Autism Spectrum DisorderR01MH117653 · NIMH · DREXEL UNIVERSITY · PI SHEA, LINDSAY LAWER · 2018 to 2021
$2.1M
Executive dysfunction as a treatment target for DS clinical trials: An evaluation of its real-world and neural correlates.R21HD106164 · NICHD · DREXEL UNIVERSITY · PI LEE, NANCY RAITANO, WALLACE, GREGORY L · 2021 to 2022
$541k
Evaluating a novel approach-avoidance model of repetitive behaviors in autistic adolescents: A multi-method studyR21MH129777 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI YERYS, BENJAMIN · 2022 to 2023
$468k
NICHD NIH HHS P50 HD105354NICHD NIH HHS P50 HD111142NICHD NIH HHS R21 HD106164NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH117653NIMH NIH HHS R01 MH133838NIMH NIH HHS R21 MH129777
6 · The paper itself

Abstract

Importance: Autistic adults experience suboptimal health outcomes. Likewise, attention-deficit/hyperactivity disorder (ADHD) is linked to poor health outcomes in the general population, yet little is known about co-occurring ADHD and its links with poor health outcomes among autistic adults. Objective: To determine the prevalence of ADHD and ADHD medication prescriptions and to examine associations between health outcomes and both ADHD co-occurrence and ADHD medication prescriptions among autistic adults. Design, Setting, and Participants: Population-based cohort study of US Medicaid-enrolled adults aged 18 years and older, including autistic adults with and without co-occurring intellectual disability (ID), adults with ID without autism, and adults from a random sample of Medicaid-enrolled individuals from 2008 to 2019. Analyses were completed September 2023 to September 2024. Exposures: Autism, ADHD, and ID using validated algorithms from the Chronic Conditions Warehouse. Main Outcomes and Measures: Prevalence rates of co-occurring ADHD, ADHD medication prescriptions, substance use, cardiovascular conditions, injury in autism without ID, ID without autism, autism with ID, and the general population. Results: The study included 3 506 661 patients (mean [SD] age, 33.5 [15.6] years; 1 854 892 [52.9%] female; 702 694 [20.0%] Black, 587 048 [16.7%] Hispanic, and 1 786 703 [60.0%] White). Compared with the general Medicaid-enrolled population (1 846 102 patients), which had 49 523 patients (2.7%) with co-occurring ADHD diagnoses, this study found elevated rates of ADHD in autism without ID (280 195 patients [26.7%]; prevalence ratio [PR], 5.1; 95% CI, 4.4-5.9), autism with ID (261 061 patients [40.2%]; PR, 6.8; 95% CI, 6.0-7.7), and ID without autism (1 119 303 patients [19.0%]; PR, 4.4; 95% CI, 4.0-5.0). A total of 117 704 adults (26.6%) with ADHD received an ADHD medication prescription. The study identified that rates of substance use were higher among clinical groups with co-occurring ADHD. For example, 9886 of 74 675 autistic adults with ADHD (13.2%) had substance use disorder, compared with 11 782 of 205 520 autistic adults with no ADHD (5.7%). ADHD diagnoses were associated with higher rates of all health outcomes, regardless of group. Substance use was higher in both ID groups with ADHD diagnoses and ADHD medications, whereas injury and cardiovascular condition rates were lower in all ADHD groups who received ADHD medications. Conclusions and Relevance: In this cohort study of Medicaid-enrolled adults, autistic adults experienced high rates of co-occurring ADHD and were more likely to receive ADHD medication prescriptions than adults in the general population. Negative health outcome rates are higher among autistic people with co-occurring ADHD, although ADHD medication prescriptions are associated with lower rates of negative health outcomes. Treating ADHD may improve health among autistic adults.

Indexed as

Attention Deficit Disorder with HyperactivityAutistic DisorderMedicaidAdolescentAdultCohort StudiesComorbidityFemaleHumansIntellectual DisabilityMaleMiddle AgedPrevalenceUnited StatesYoung Adult

Identifiers

PMID39937481
PMCPMC11822541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.