Evidence map›Paper›PMID 39937435›Full record

ArticleMacromolecular bioscience2025

A Silibinin-Poly(ε-Caprolactone) Conjugate as an Enhanced Anticancer Agent.

Fabiana Vento, Anna Privitera, Giuseppe Caruso, Angelo Nicosia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fabiana VentoDepartment of Chemical Sciences and INSTM UdR of Catania, University of Catania, V.le A. Doria 6, Catania, 95125, Italy.ORCID 0000-0001-5968-0942
Anna PriviteraDepartment of Drug and Health Sciences, University of Catania, V.le A. Doria 6, Catania, 95125, Italy.ORCID 0000-0003-2919-6150
Giuseppe CarusoDepartment of Drug and Health Sciences, University of Catania, V.le A. Doria 6, Catania, 95125, Italy.ORCID 0000-0003-1571-5327
Angelo NicosiaDepartment of Chemical Sciences and INSTM UdR of Catania, University of Catania, V.le A. Doria 6, Catania, 95125, Italy.ORCID 0000-0003-0802-7358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly(ε-caprolactone) (PCL) is a hydrolytically degradable biopolyester used in drug delivery to enhance drug solubility and bioavailability, where drugs are typically incorporated physically within the biopolymeric matrix rather than covalently bonded, due to the limited availability of functional groups required for covalent attachment. In pursuit of developing a facile method for the production of a biopolyester-drug covalent conjugate with effective drug loading capacity, this study reports the synthesis of a covalent Silibinin-PCL conjugate (Sil-PCL

Indexed as

Antineoplastic AgentsPolyestersSilymarinCaco-2 CellsCell SurvivalHumansSilybinAntineoplastic AgentspolycaprolactonePolyestersSilybinSilymarinanticancer activityfacile synthesishuman colorectal adenocarcinomapoly(ε‐caprolactone)silibinin

Identifiers

PMID39937435
PMCPMC11995842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.