ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Pain and fatigue in Parkinson's disease: advances in diagnosis and management.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Pain in Parkinson's disease: bridging pathophysiology, clinical features, and personalized management.The journal of headache and pain · 2026Review
- Types of Pain in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Gender differences in non-motor symptoms in Parkinson's disease: a multicenter longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Non-Pharmacological interventions for managing fatigue in parkinson's disease: A systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2026Review
- Fatigue-Inducing Protocols in Parkinson's Disease: Implications for Gait Assessment and Rehabilitation: A Systematic Review.Parkinson's disease · 2026Review
- Review
- Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson's disease-related fatigue.Frontiers in aging neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-motor symptoms affect over 90% of people with Parkinson's disease at all stages, with pain and fatigue being among the most prevalent yet often neglected in clinical practice. Despite their significant impact, these symptoms are frequently underdiagnosed and inadequately treated, adding substantial burden to patients' lives. The lack of a clear definition and classification of these symptoms has led neurologists to underestimate their presence among people with Parkinson's disease and limited the ability to address them with mechanism-based care and effective treatments. Managing these symptoms is challenging because of the lack of robust, specifically designed, randomized-controlled trials on effective treatments. This review delves into the current understanding of diagnosing, assessing, and treating pain and fatigue in Parkinson's disease, highlighting critical knowledge gaps and suggesting future research directions. The framework emphasizes improving classification methods, deepening our understanding of the underlying pathophysiology, evaluating treatment impacts on pain and fatigue, and leveraging longitudinal data collection through consensus-based methodology. By addressing these critical areas, we strive to enhance the management of these debilitating non-motor symptoms and ultimately improve patients' quality of life.
Indexed as
Identifiers
39937423What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.