Evidence map›Paper›PMID 39937413›Full record

ArticleApplied biochemistry and biotechnology2025

Untargeted Metabolomics and Proteomics-Based Research of the Long-Term Exercise on Human Body.

Wenqian Zhuang, Yang Wang, Xin Xu, Jingjing Zhao

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenqian ZhuangShanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai, 200438, China.
Yang WangShanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai, 200438, China.
Xin XuShanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai, 200438, China.
Jingjing ZhaoShanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai, 200438, China. zhaojingjing@sus.edu.cn.ORCID http://orcid.org/0009-0001-5344-8859

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular long-term exercise can benefit the body and reduce the risk of several diseases, such as cardiovascular disease, diabetes, and obesity. However, the proteomic and metabolomic changes, as well as the physiological responses associated with long-term exercise, remain incompletely understood. To investigate the effects of long-term exercise on the human body, 14 subjects with long-term exercise habits and 10 subjects without exercise habits were selected for this study. Morning urine samples were collected and analyzed for untargeted metabolomics and proteomics using liquid chromatography-mass spectrometry. A total of 404 differential metabolites and 394 differential proteins were screened in this research, and the analysis results indicated that long-term exercise may affect energy metabolism, amino acid synthesis and metabolism, nucleotide metabolism, steroid hormone biosynthesis, and the inflammatory response. These findings offer a more comprehensive understanding of the molecular effects of long-term exercise on the human body and provide a basis for future research exploring the underlying mechanisms.

Indexed as

ExerciseMetabolomicsProteomicsAdultEnergy MetabolismFemaleHumansMaleLiquid chromatography mass spectrometryLong-term exerciseMetabolomicsProteomics

Identifiers

PMID39937413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.