Evidence map›Paper›PMID 39937367›Full record

ArticleLa Radiologia medica2025

Ex-vivo 7T MRI of human explanted cirrhotic liver with HCC: quantitative and qualitative evaluation with radiological-pathological correlation.

Rosa Cervelli, Matteo Cencini, Giacomo Aringhieri, Beatrice Silvestrini, Andrea Cacciato Insilla, Daniela Campani, Davide Ghinolfi, Paolo De Simone, Michela Tosetti, Laura Crocetti

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Article in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Rosa CervelliDiagnostic and Interventional Radiology, University of Pisa, Pisa, Italy.
Matteo CenciniPisa Division, National Institute for Nuclear Physics (INFN), Pisa, Italy.
Giacomo AringhieriAcademic Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. g.aringhieri@gmail.com.ORCID http://orcid.org/0000-0003-0842-5372
Beatrice SilvestriniDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Andrea Cacciato InsillaSurgical Pathology, University of Pisa, Pisa, Italy.
Daniela CampaniSurgical Pathology, University of Pisa, Pisa, Italy.
Davide GhinolfiHepatic Surgery and Liver Transplantation, University of Pisa, Pisa, Italy.
Paolo De SimoneHepatic Surgery and Liver Transplantation, University of Pisa, Pisa, Italy.
Michela TosettiIMAGO7 Foundation, IRCCS Stella Maris, Pisa, Italy.
Laura CrocettiDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatocellular carcinoma's (HCC) pathological grading is a recognized factor influencing intrahepatic recurrence after treatment. Thus, understanding the HCC heterogeneity is crucial to select the best treatment option aiming at personalized medicine. 7T MRI can provide qualitative and quantitative data, potentially identifying imaging biomarkers for lesions characterization. MATERIALS AND

methodsFrom May 2019 to December 2019, all explanted livers of patients undergoing liver transplant were enrolled. All patients underwent whole body CT before liver transplant and all the explanted livers were evaluated (ex-vivo) by 7T MRI within 12 h from liver removal with qualitative and quantitative acquisitions, including 2D/3D magnetic resonance fingerprinting (MRF). First, two expert radiologists qualitatively and quantitatively evaluated the imaging data focusing on both lesions and surrounding tissue, comparing conventional and MRF sequences. Then, specimens were evaluated by an expert pathologist regarding both liver tissues and lesions, particularly focusing on HCC grading.

conclusionsThis work may represent the first step supporting the introduction of quantitative MR imaging (including MRF) in the clinical practice. Along with conventional protocol and dynamic contrast enhancement, the integration of quantitative MR imaging can provide imaging biomarkers useful to identify HCC lesions more prone to recurrence, leading to a better patient selection, according to a personalized medicine approach.

Indexed as

Carcinoma, HepatocellularLiver CirrhosisLiver NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHumansLiverLiver TransplantationMaleMiddle AgedCirrhosisHCCImaging biomarkersLiver transplantMagnetic resonance fingerprintingQuantitative MR imagingRadiological-pathological correlationUltra-high field MRI

Identifiers

PMID39937367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.