ReviewCurrent osteoporosis reports2025
Calcium Supplementation- Efficacy and Safety.
Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- From metabolic node to smart building block: α-Ketoglutarate-empowered biomaterials for programmable cell fate.Materials today. Bio · 2026Review
- Dietary and supplemental calcium intake and bone changes during antiresorptive osteoporosis treatment in older women: a longitudinal observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Concurrent Calcium and Magnesium Determination by Ion Chromatography: An Approach to Avoid Interferences That Compromise Analysis.Biomedical chromatography : BMC · 2026Article
- Screening of probiotics for promoting mineral absorption based onFrontiers in microbiology · 2026Article
- Molecular Mechanisms and Therapeutic Potential of Puerariae Lobatae Radix in Bone Metabolism: A Comprehensive Review.Drug design, development and therapy · 2026Review
- Bone Health Following Lifestyle-Induced Weight Loss in Individuals With Overweight/Obesity: A Narrative Review.Obesity (Silver Spring, Md.) · 2026Review
- Supplements for bone health.Archives of endocrinology and metabolism · 2025Review
- Supplementation with a Salmon Bone Complex (CalGoBiomedicines · 2025Article
- Dietary interventions and nutritional strategies for menopausal health: a mini review.Frontiers in nutrition · 2025Review
- Effect of topical papaverine on parathyroid function preservation after total thyroidectomy: a retrospective cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo assess the efficacy of calcium supplements in preventing fractures, and to review their adverse effects, particularly on the cardiovascular system. RECENT
findingsThere is now a large body of trial evidence demonstrating that calcium supplements do not prevent fractures in community-dwelling adults. They commonly produce gastrointestinal side-effects, sometimes serious, and increase the risk of renal calculi. Meta-analyses of adverse events from clinical trials suggest that the risk of MI is increased by 10-20% with calcium supplementation, though dietary calcium intake does not appear to be a cardiac risk factor. Ingestion of a calcium bolus increases circulating calcium concentrations for the following 8 h, accompanied by acute increases in blood coagulability and calcification propensity, with blood pressures > 5 mmHg higher than placebo-treated individuals. Mendelian randomization studies demonstrate that circulating calcium levels are a significant risk factor for cardiovascular disease, so the acute calcium-elevating effect of supplements might contribute to increased cardiovascular risk. The current balance of evidence suggests that calcium supplements have little role in the prevention or treatment of osteoporosis, since estrogen and bisphosphonates prevent fractures without their co-administration. Specific studies are needed to address whether calcium is benficial with anabolic bone medicines.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.