Evidence map›Paper›PMID 39937296›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy.

Aishwarya Bandla, Rachel Wong, Priyadharshini Santhanakrishnan, Gayathiri Magarajah, Yang En Yee, Wei Yen Ng, Samuel Ow, Gloria Chan, Joan Choo, Siew Eng Lim and 13 more

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Aishwarya BandlaThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore. aishwarya.bandla@nus.edu.sg.
Rachel WongDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Priyadharshini SanthanakrishnanThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Gayathiri MagarajahThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Yang En YeeThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Wei Yen NgThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Samuel OwDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Gloria ChanDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Joan ChooDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Siew Eng LimDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Andrea WongDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Joy VijayanDepartment of Neurology, National University Health System, Singapore, Singapore.
Richard PaxmanPaxman Coolers Ltd., Huddersfield, UK.
Yee Mei LeeNational University Cancer Institute, National University Health System, Singapore, Singapore.
Fu HuiNational University Cancer Institute, National University Health System, Singapore, Singapore.
Zarinah HairomNational University Cancer Institute, National University Health System, Singapore, Singapore.
Emily AngNational University Cancer Institute, National University Health System, Singapore, Singapore.
Charles LoprinziDepartment of Medical Oncology, Mayo Clinic, Rochester, USA.
Nitish ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, USA.
Soo Chin LeeDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Nesaratnam KumarakulasingheDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Joline LimDepartment of Hematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore. csilsjj@nus.edu.sg.
Raghav SundarThe N.1 Institute for Health, National University of Singapore, Singapore, Singapore. raghav.sundar@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionScalp cooling is standard-of-care for prevention of chemotherapy-induced alopecia (CIA), with proven safety and efficacy. Limb cryotherapy has shown promise in preventing chemotherapy-induced peripheral neuropathy (CIPN). The safe application of concomitant scalp and limb cryotherapies during chemotherapy is crucial due to concerns about potential interactions, including central hypothermia, yet limited data exist on their safe delivery in this context. Here we report a prospective, single-arm study assessing feasibility, safety, and tolerability of concomitant scalp cooling and limb cryocompression in healthy volunteers, and in cancer patients undergoing chemotherapy.

methodsSafety and tolerability of concomitant scalp cooling and limb cryocompression were evaluated in healthy volunteers and then in cancer patients receiving weekly paclitaxel chemotherapy. Limb cryocompression was administered starting at 11 °C, with thermoregulation allowed up to 25 °C to accommodate patient tolerance. Core body temperature changes, adverse events (CTCAE v4.0), and tolerance to cryotherapy were documented. EORTC Quality of Life Questionnaire-CIPN20 scores were evaluated before the start of chemotherapy (QoL

resultsConcomitant scalp and limb cryocompression at 11 °C was safe and tolerable in healthy volunteers (n = 3). Fifteen patients enrolled in the study and 13 completed the entire treatment, with negligible core body temperature changes (- 0.18 °C ± 0.37). Eight patients completed all 12 cycles of cryocompression at 11 °C while some required thermoregulation (range 14 °C to 18 °C). One patient completed all cryotherapy cycles at 25 °C and another withdrew due to intolerance to 25 °C. There were no occurrences of ≥ Grade 2 neuropathy. QoL was preserved and scores remained stable at QoL

conclusionDelivery of concomitant scalp cooling and limb cryocompression is feasible, safe, and tolerable. Larger studies are needed, and currently ongoing, to investigate the efficacy of limb cryocompression for CIPN prevention.

Indexed as

AlopeciaAntineoplastic Agents, PhytogenicCryotherapyHypothermia, InducedPaclitaxelPeripheral Nervous System DiseasesAdultAgedExtremitiesFeasibility StudiesFemaleHumansMaleMiddle AgedNeoplasmsProspective StudiesAntineoplastic Agents, PhytogenicPaclitaxelChemotherapy-induced peripheral neuropathyCryocompressionCryotherapyFrozen glovesLimb hypothermiaScalp cooling

Identifiers

PMID39937296
PMCPMC11821790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.