Evidence map›Paper›PMID 39937249›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Testosterone Concentration and Incident Depression in Older Men: A Longitudinal Cohort Study.

Malcolm Forbes, Mojtaba Lotfaliany, Cammie Tran, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Michael Berk

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Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Malcolm ForbesThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-8339-6471
Mojtaba LotfalianyThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Cammie TranSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Mohammadreza MohebbiThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-1249-6149
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-1049-5129
Michael BerkThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
National Health and Medical Research Council 334047NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682NIH HHS U01AG029824
6 · The paper itself

Abstract

backgroundTestosterone has been implicated in mood regulation, yet its role in the development and treatment of depression remains unclear. This study investigated the association between testosterone concentrations and the incidence of depression in older men.

methodsWe utilized data from 4 107 men aged 70 years and older who participated in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE-XT studies. Serum total testosterone concentrations were measured at baseline and year 3. Depressive symptoms were assessed annually using the CES-D-10 scale, with incident depression defined as a CES-D-10 score of ≥8. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) for incident depression, adjusted for potential confounders.

resultsDuring a median follow-up of 8.4 years, 1 449 participants experienced an episode of depression. Baseline total testosterone concentrations were not significantly associated with the risk of incident depression, whether treated as continuous variables (HR 1.00, 95% CI 0.99-1.01) or when categorized into quintiles. Similarly, changes in testosterone concentrations from baseline to year 3 did not predict incident depression (aHR 1.03, 95% CI 0.99-1.08). A subgroup analysis focusing on men with biochemical evidence of hypogonadism also found no association with incident depression.

conclusionsOur findings do not support an association between testosterone concentrations and the risk of developing depression in older men. These results suggest that testosterone is not an important factor in the pathogenesis of depression in this population. There may still be individual variability in response to testosterone changes and its potential impact on mood disorders.

Indexed as

DepressionTestosteroneAgedAged, 80 and overHumansIncidenceLongitudinal StudiesMaleProportional Hazards ModelsRisk FactorsTestosteroneDepressionDepressive symptomsMental healthMood disordersPsychiatryTestosterone

Identifiers

PMID39937249
PMCPMC12070475

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