Evidence map›Paper›PMID 39937180›Full record

ArticleeLife2025

Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock.

Andrea Brenna, Micaela Borsa, Gabriella Saro, Jürgen A Ripperger, Dominique A Glauser, Zhihong Yang, Antoine Adamantidis, Urs Albrecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea BrennaDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-8542-9855
Micaela BorsaZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-7634-7738
Gabriella SaroDepartment of Biology, University of Fribourg, Fribourg, Switzerland.
Jürgen A RippergerDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-9345-5172
Dominique A GlauserDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-3228-7304
Zhihong YangDepartment of Endocrinology, Metabolism, and Cardiovascular System, Section of Medicine, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-4133-5099
Antoine AdamantidisZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Urs AlbrechtDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-0663-8676

Funding

European Research Council CoG-725850Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_197607Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_219438/1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_219880/1University of Fribourg 310030_219438/1
6 · The paper itself

Abstract

The circadian clock enables organisms to synchronize biochemical and physiological processes over a 24 hr period. Natural changes in lighting conditions, as well as artificial disruptions like jet lag or shift work, can advance or delay the clock phase to align physiology with the environment. Within the suprachiasmatic nucleus (SCN) of the hypothalamus, circadian timekeeping and resetting rely on both membrane depolarization and intracellular second-messenger signaling. Voltage-gated calcium channels (VGCCs) facilitate calcium influx in both processes, activating intracellular signaling pathways that trigger

Indexed as

Circadian ClocksCyclin-Dependent Kinase 5LightAnimalsCalciumCircadian RhythmMaleMiceMice, Inbred C57BLSignal TransductionSuprachiasmatic NucleusCalciumCdk5 protein, mouseCyclin-Dependent Kinase 5clock genesenvironmental signaljet lagkinaseslight adaptationmouseneuroscienceshift work

Identifiers

PMID39937180
PMCPMC11820109

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.