ArticleFoot & ankle international2025
Talar Morphology of Charcot-Marie-Tooth Patients With Cavovarus Feet.
Article in Foot & ankle international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Charcot-Marie-Tooth Cavovarus Foot: Current Concepts and Emerging Strategies for Deformity Correction.Journal of clinical medicine · 2026Review
- Asymmetric Cavovarus Deformity Presentation in Charcot-Marie-Tooth Disease.Foot & ankle orthopaedics · 2026Article
- Statistical Shape Modeling Characterization of Cavovarus Deformity Between Demyelinating and Axonal Subtypes of Charcot-Marie-Tooth Disease.Foot & ankle international · 2025Article
- Ultrasound Evaluation of Plantar Fascia in Individuals with Charcot-Marie-Tooth Disease: An Exploratory Study.Life (Basel, Switzerland) · 2025Article
- Osseous morphology differences in the foot and ankle associated with Charcot-Marie-Tooth disease.JBMR plus · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundCharcot-Marie-Tooth disease (CMT), a common inherited neurologic disorder, significantly impacts the morphology of foot bones, particularly the talus. The disease has been classified into types based on specific mutations, with the most common being CMT type 1 (CMT1; demyelinating) and CMT type 2 (CMT2; axonal). However, the specific osseous morphologic variations in CMT patients and their major genetic subgroups remain insufficiently understood, posing challenges in clinical management and surgical intervention.
methodsThis study analyzed talar morphology in individuals with CMT compared with a healthy control group, employing a single-bone statistical shape model and talar neck offset angle measurements. Participants included 18 CMT individuals (yielding 29 tali) and 43 healthy controls. For individuals with CMT, the average age at diagnosis was 36.5 ± 19.8 years, with a mean interval of 8.6 years between diagnosis and imaging. Talar morphology was evaluated using weightbearing computed tomography and subsequent morphologic and angular analysis.
resultsDifferences were observed in talar morphology between CMT and healthy individuals. Notably, CMT1 and CMT2 tali exhibited a flatter talar dome and more medial talar head and neck compared with controls. Additionally, the CMT1 and CMT2 subgroups both had a more medially oriented talar neck based on the talar neck offset angle compared with the controls.
conclusionThe findings illustrate significant morphologic variations in the talus of CMT patients, indicating the need for type-specific clinical approaches in treating CMT-related foot deformities. Understanding these talar variations is crucial for tailoring surgical techniques and orthotic designs, and developing effective rehabilitation protocols for individuals with CMT, potentially improving patient care and outcomes.
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