Evidence map›Paper›PMID 39937017›Full record

ArticleCells2025

The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study.

Xiaogang Chu, Mahmoud Elashiry, Angelica Carroll, Celine Joyce Cornelius Timothius, Christopher W Cutler, Ranya Elsayed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The Role of Cellular Senescence in Oral Health and Disease.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. PKM2Bioactive materials · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaogang ChuDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0007-8020-9750
Mahmoud ElashiryDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Angelica CarrollDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Celine Joyce Cornelius TimothiusDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3246-6206
Christopher W CutlerDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ranya ElsayedDepartment of Periodontics, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-5034-4109

Funding

DC exosome therapy to resolve inflammatory bone loss and oral infectionR01DE029468 · NIDCR · AUGUSTA UNIVERSITY · PI ELSAYED, RANYA · 2021 to 2025
$1.8M
The role of oral microbially induced exosomes in Alzheimer's disease pathogenesisR01AG087335 · NIA · AUGUSTA UNIVERSITY · PI Ranya Elsayed · 2025 to 2026
$1.1M
NIA NIH HHS R01 AG087335NIDCR NIH HHS R01 DE029468NIH HHS 5R01DE029468-04A1
6 · The paper itself

Abstract

The occurrence and severity of periodontitis (PD) tend to increase with age, and yet the underlying mechanisms remain unclear. Immune senescence is known to be triggered in mice and humans as they age. Experimental PD in mice has been shown to induce senescence biomarkers p16

Indexed as

Cellular SenescencePeriodontitisAnimalsCyclin-Dependent Kinase Inhibitor p16Disease Models, AnimalHumansMaleMiceMice, Inbred C57BLCyclin-Dependent Kinase Inhibitor p16bone lossP16-3MRperiodontal diseaseperiodontitissenescence

Identifiers

PMID39937017
PMCPMC11817363

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.