Evidence map›Paper›PMID 39936999›Full record

ArticleCells2025

The Autocrine Impact of Nerve Growth Factor on Sheep Uterine Epithelial Cells.

Gabriella Guelfi, Rolando Pasquariello, Cecilia Dall'Aglio, Francesca Mercati, Chiara Suvieri, Carmela Conte, Camilla Capaccia, Marcelo Ratto, Margherita Maranesi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriella GuelfiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0003-3695-9275
Rolando PasquarielloDepartment of Agricultural and Environmental Sciences-Production, Territory, Agroenergy, University of Milan, Via Celoria 2, 20133 Milano, Italy.ORCID 0000-0003-3191-7009
Cecilia Dall'AglioDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0001-6451-3751
Francesca MercatiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-8799-1200
Chiara SuvieriDepartment of Medicine and Surgery, University of Perugia, Piazzale Settimio Gambuli 1, 06129 Perugia, Italy.ORCID 0000-0002-0634-0386
Carmela ConteDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy.ORCID 0000-0003-2456-6300
Camilla CapacciaDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1040-6245
Marcelo RattoFaculty of Veterinary Sciences, Austral University of Chile, Campus Isla Teja, Calle Las Encinas 220, Valdivia P.O. Box 567, Chile.
Margherita MaranesiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1727-4118

Funding

Fondazione Cassa Risparmio di Perugia, Italy - Call for applications for the Scientific and Tech-nological Research Sector 2022 Grant Number 2022.0395
6 · The paper itself

Abstract

Nerve growth factor (NGF) plays a critical role in reproduction through paracrine and endocrine mechanisms. However, its autocrine effects on uterine receptivity and inflammatory pathways remain unknown. This study is the first to demonstrate NGF's direct autocrine action on sheep endometrial luminal epithelial cells (SELECs), primary cultures treated with NGF for 12, 24, and 48 h, with or without the NTRK1 antagonist. NGF significantly increased PGE2 (

Indexed as

Autocrine CommunicationEpithelial CellsNerve Growth FactorUterusAnimalsCells, CulturedEndometriumFemaleReceptor, trkASheepNerve Growth FactorReceptor, trkAautocrine signalingendometrial epithelial cellsnerve growth factorprostaglandinsheep reproductive physiology

Identifiers

PMID39936999
PMCPMC11817128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.