Evidence map›Paper›PMID 39936987›Full record

ArticleCells2025

Patients with Irritable Bowel Syndrome Exhibit Aberrant Expression of Endogenous Retroviruses and SETDB1.

Pier-Angelo Tovo, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Cristina Calvi, Paola Montanari, Marco Tizzani, Demis Pitoni, Simone Frara, Elisa Tribocco, Stefano Gambarino and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pier-Angelo TovoDepartment of Public Health and Pediatric Sciences, University of Turin, Piazza Polonia 94, 10126 Turin, Italy.
Davide Giuseppe RibaldoneDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.
Gian Paolo CavigliaDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.ORCID 0000-0002-0529-9481
Cristina CalviPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy.
Paola MontanariPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy.
Marco TizzaniDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.
Demis PitoniDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.
Simone FraraDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.
Elisa TriboccoDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.
Stefano GambarinoPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy.
Marta GuarigliaDepartment of Medical Sciences, Division of Gastroenterology, University of Turin, 10123 Turin, Italy.ORCID 0000-0003-1389-7278
Ilaria GallianoPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy.ORCID 0000-0002-1273-3178
Massimiliano BergalloPediatric Laboratory, Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy.ORCID 0000-0002-9291-1332

Funding

CRT Foundation BERM_CRT_24_01
6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is a common disease, whose etiopathogenesis is poorly understood. Human endogenous retroviruses (HERVs) originate from ancient infections of germinal cells and represent 8% of our DNA. Most HERVs have become defective due to the accumulated mutations; some can, however, still be activated, and their altered expressions have been associated with a number of chronic inflammatory and immune-mediated disorders, including gastrointestinal diseases. Retroviral transcription is modulated by TRIM28 and SETDB1, which also participate in the regulation of epigenetic mechanisms and in shaping the immune system. Expressions of HERVs and TRIM28/SETDB1 have not been investigated in patients affected by IBS. Using a PCR real-time Taqman amplification assay, we explored the RNA levels of HERV-H-pol, HERV-K-pol, and HERV-W-pol; syncytin 1 (SYN1), SYN2, and HERV-W-env; and TRIM28 and SETDB1 in the peripheral blood of 37 IBS patients and healthy controls (HCs) of similar age. The transcript levels were higher in IBS patients than in HCs for all HERVs except for HERV-W-pol, with significant

Indexed as

Endogenous RetrovirusesHistone-Lysine N-MethyltransferaseIrritable Bowel SyndromeAdultCase-Control StudiesFemaleHumansMaleMiddle AgedTripartite Motif-Containing Protein 28Histone-Lysine N-MethyltransferaseSETDB1 protein, humanTRIM28 protein, humanTripartite Motif-Containing Protein 28human endogenous retrovirusesirritable bowel syndromepathogenesisSETDB1TRIM28

Identifiers

PMID39936987
PMCPMC11817187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.