Evidence map›Paper›PMID 39936983›Full record

ArticleCells2025

Chronic IL-1-Exposed LNCaP Cells Evolve High Basal p62-KEAP1 Complex Accumulation and NRF2/KEAP1-Dependent and -Independent Hypersensitive Nutrient Deprivation Response.

Haley Dahl-Wilkie, Jessica Gomez, Anastasia Kelley, Kirti Manjit, Basir Mansoor, Preethi Kanumuri, Sammy Pardo, Dana Molleur, Rafah Falah, Anisha R Konakalla and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Haley Dahl-WilkieBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Jessica GomezBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Anastasia KelleyBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Kirti ManjitBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Basir MansoorBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0009-0007-3581-3422
Preethi KanumuriBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0009-0009-6550-7228
Sammy PardoDepartment of Biochemistry & Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Dana MolleurDepartment of Biochemistry & Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Rafah FalahBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Anisha R KonakallaBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Morolake OmiyaleBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.
Susan WeintraubDepartment of Biochemistry & Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Nikki A DelkBiological Sciences Department, The University of Texas at Dallas, Richardson, TX 75080, USA.

Funding

Orbitrap XL/ETD Mass SpectrometerS10RR025111 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WEINTRAUB, SUSAN T · 2009 to 2009
$776k
American Cancer Society RSG-20-138-01-TBENCRR NIH HHS S10 RR025111
6 · The paper itself

Abstract

Chronic inflammation is a cancer hallmark and chronic exposure to interleukin-1 (IL-1) transforms castration-sensitive prostate cancer (PCa) cells into more fit castration-insensitive PCa cells. p62 is a scaffold protein that protects cells from nutrient deprivation via autophagy and from cytotoxic reactive oxygen via NFκB and NRF2 antioxidant signaling. Herein, we report that the LNCaP PCa cell line acquires high basal accumulation of the p62-KEAP1 complex when chronically exposed to IL-1. p62 promotes non-canonical NRF2 antioxidant signaling by binding and sequestering KEAP1 to the autophagosome for degradation. But despite high basal p62-KEAP1 accumulation, only two of several NRF2-induced genes analyzed,

Indexed as

Interleukin-1Kelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2NutrientsProstatic NeoplasmsSequestosome-1 ProteinAutophagyCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleRNA-Binding ProteinsSignal TransductionInterleukin-1KEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2NutrientsP62 protein, humanRNA-Binding ProteinsSequestosome-1 ProteinSQSTM1 protein, humanchronic IL-1GCLCHMOX1NRF2p62-KEAP1

Identifiers

PMID39936983
PMCPMC11816438

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.