Evidence map›Paper›PMID 39936955›Full record

ArticleCells2025

Altered ATP13A2/PARK9 Levels Influence α-Synuclein Accumulation in Neurons via Phagocytosis and Secretion in Glial Cells.

Taiji Tsunemi, Yuta Ishiguro, Asako Yoroisaka, Dou Feng, Nobutaka Hattori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taiji TsunemiDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-0021-0708
Yuta IshiguroDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Asako YoroisakaDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Dou FengDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-2034-2556

Funding

AMED JP121ek0109429AMED JP22wm0425015AMED JP24dk0207072JSPS KAKENHI 18K07510JSPS KAKENHI 21K07444JSPS KAKENHI 24K10628
6 · The paper itself

Abstract

(1) Background: Parkinson's disease (PD) is characterized by the pathological accumulation of α-synuclein (α-syn) containing Lewy bodies (LBs) and Lewy neurites (LNs) within neurons. Growing evidence indicates that α-syn may propagate throughout the nervous system in a manner similar to prion-like transmission. Extracellular vesicles (EVs) may contribute to this pathway. We and others have reported that ATP13A2/PARK9 deficiency results in decreased EVs while its overexpression leads to increased EV generation. For analyzing EV-mediated α-syn secretion in neighboring neurons, we planned to alter Atp13a2 levels in vivo. (2) Methods: Three months after inoculating mouse α-syn fibrils into the striatum of

Indexed as

alpha-SynucleinNeurogliaNeuronsPhagocytosisProton-Translocating ATPasesAnimalsAstrocytesExtracellular VesiclesHumansLewy BodiesMiceMice, Inbred C57BLMice, KnockoutParkinson Diseasealpha-SynucleinATP13A2 protein, humanATP13A2 protein, mouseProton-Translocating ATPasesATP13A2extracellular vesiclesParkinson’s disease

Identifiers

PMID39936955
PMCPMC11817767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.