Evidence map›Paper›PMID 39936628›Full record

ArticleAngewandte Chemie (International ed. in English)2025

A Nanotherapeutic Agent for Synergistic Tumor Therapy: Co-Activation of Photochemical-Biological Effects.

Junwei Liu, Yang Liu, Songsong Zhi, Yonggang Yang, Heejeong Kim, Dapeng Wu, Ge Wang, Tony D James, Juyoung Yoon, Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junwei LiuSchool of Chemistry and Chemical Engineering, Henan Normal University.
Yang LiuSchool of Chemistry and Chemical Engineering, Henan Normal University.
Songsong ZhiSchool of Chemistry and Chemical Engineering, Henan Normal University.
Yonggang YangSchool of Chemistry and Chemical Engineering, Henan Normal University.
Heejeong KimDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea.
Dapeng WuSchool of Chemistry and Chemical Engineering, Henan Normal University.
Ge WangCollege of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453007, P. R. China.
Tony D JamesSchool of Chemistry and Chemical Engineering, Henan Normal University.ORCID 0000-0002-4095-2191
Juyoung YoonDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea.ORCID 0000-0002-1728-3970
Hua ZhangSchool of Chemistry and Chemical Engineering, Henan Normal University.ORCID 0000-0002-7593-4946

Funding

National Natural Science Foundation of China U21A20314National Research Foundation of Korea 2022M3E5F3080873National Research Foundation of Korea 2022R1A2C3005420
6 · The paper itself

Abstract

Single-mode photodynamic therapy (PDT) based on photochemical reactions is limited by the tumor microenvironment, which reduces the ablation efficiency for solid tumors. Making it vital to seek ways to improve the tumor therapeutic effect. Based on this, we propose a dual-mode intelligent nanotherapeutic system (HAP@BMPns) based on photochemical-biological effects. HAP@BMPns is composed of an acid-responsive high-calcium biomimetic nanomaterial (HAP) and photosensitizer (BMP), which can spontaneously activate photochemical (Type-I PDT) and biological effects for synergistic cancer therapy. HAP@BMPns breaks down upon entering tumor cells under acidic conditions, releasing a large amount of Ca

Indexed as

Antineoplastic AgentsBiomimetic MaterialsNanoparticlesNanostructuresNeoplasmsPhotochemotherapyPhotosensitizing AgentsApoptosisCalciumCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHumansAntineoplastic AgentsCalciumPhotosensitizing AgentsCa2+ OverloadPhotodynamic TherapySynergistic EffectsTheranosticsTumor Therapy

Identifiers

PMID39936628
PMCPMC12015378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.