Evidence map›Paper›PMID 39936615›Full record

ArticleAutophagy2025

ESRRA (estrogen related receptor, alpha) induces ribosomal protein RPLP1-mediated adaptive hepatic translation during prolonged starvation.

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Gupta, Suganya Sakthivel, Nah Jiemin, Kabilesh Arul, Keziah Tikno, Sung-Hee Park and 9 more

Abstract read
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. RNA Sequencing in AdultbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Madhulika TripathiLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Karine GauthierDépartement de Biologie, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Lyon, Cedex, France.
Reddemma SandireddyLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Jin ZhouLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Priyanka GuptaLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Suganya SakthivelLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Nah JieminCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Kabilesh ArulLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Keziah TiknoLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Sung-Hee ParkDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Yajun WuDepartment of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore, Singapore.
Lijin WangCentre for Computational Biology, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Boon-Huat BayDepartment of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore, Singapore.
Lena HoCardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Vincent GiguereGoodman Cancer Research Centre, McGill University, Montreal, Québec, Canada.
Sujoy GhoshCentre for Computational Biology, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Donald P McDonnellDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Paul M YenLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
Brijesh K SinghLaboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.ORCID 0000-0003-4615-3988

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Molecular Basis of Exercise-induced Changes in HDL FunctionR01HL146462 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SARZYNSKI, MARK ANDREW · 2019 to 2023
$3.6M
Manipulating normal estrogen physiology as a therapeutic approach in cancerR01CA276089 · NCI · DUKE UNIVERSITY · PI Donald P McDonnell · 2023 to 2026
$2.2M
NCI NIH HHS R01 CA276089NHLBI NIH HHS R01 HL146462NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Protein translation is an energy-intensive ribosome-driven process that is reduced during nutrient scarcity to conserve cellular resources. During prolonged starvation, cells selectively translate specific proteins to enhance their survival (adaptive translation); however, this process is poorly understood. Accordingly, we analyzed protein translation and mRNA transcription by multiple methods

Indexed as

LiverProtein BiosynthesisReceptors, EstrogenRibosomal ProteinsStarvationAnimalsAutophagyERRalpha Estrogen-Related ReceptorHumansLysosomesMiceERRalpha Estrogen-Related ReceptorReceptors, EstrogenRibosomal Proteins60S acidic ribosomal protein P1 (RPLP1)autophagyestrogen related receptor alpha (ESRRA/ERRα)lysosomestarvationtranslation

Identifiers

PMID39936615
PMCPMC12087656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.