Evidence map›Paper›PMID 39936582›Full record

ArticleMolecular biology and evolution2025

Phylogeography Analysis Reveals Rabies Epidemiology, Evolution, and Transmission in the Philippines.

Liang Zhang, Jeffrey Cruz, Yao Tian, Yuyang Wang, Jianfeng Jiang, Riva Marie Gonzales, Rachel R Azul, Rainelda C Dela Peña, Sheng Sun, Yan Liu and 5 more

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Liang ZhangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0009-0001-4987-5487
Jeffrey CruzAnimal Disease Diagnosis and Reference Laboratory, Veterinary Laboratory Division, Department of Agriculture Bureau of Animal Industry, Quezon, Philippines.ORCID 0009-0005-0355-3633
Yao TianState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0009-0003-9107-5269
Yuyang WangInstitute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0002-7164-700X
Jianfeng JiangState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0000-0002-7625-0570
Riva Marie GonzalesAnimal Disease Diagnosis and Reference Laboratory, Veterinary Laboratory Division, Department of Agriculture Bureau of Animal Industry, Quezon, Philippines.ORCID 0009-0006-9158-054X
Rachel R AzulAnimal Disease Diagnosis and Reference Laboratory, Veterinary Laboratory Division, Department of Agriculture Bureau of Animal Industry, Quezon, Philippines.ORCID 0009-0006-0415-4359
Rainelda C Dela PeñaAnimal Disease Diagnosis and Reference Laboratory, Veterinary Laboratory Division, Department of Agriculture Bureau of Animal Industry, Quezon, Philippines.ORCID 0009-0008-1187-9678
Sheng SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.ORCID 0009-0000-6468-4809
Yan LiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.ORCID 0009-0006-6359-2615
Tao JiangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0000-0003-1908-2926
Liqun FangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.ORCID 0000-0002-4981-1483
Changchun TuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.ORCID 0000-0002-8134-7502
Wenjie GongState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0000-0002-7239-7188
Ye FengChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.ORCID 0000-0002-3849-2309

Funding

National Key Research and Development Program of China 2022YFD1800100Philippine Council for Health Research and Development-Department of Science and Technology
6 · The paper itself

Abstract

Rabies, caused by rabies virus, is a severe public health problem in the Philippines, where animal rabies epidemiology had been extensively investigated, but little is known about the national epidemiologic situations since 2010. Here, we report a 12-year nationwide animal rabies surveillance with systematic phylogenetic analysis, in which 353 whole genomes of rabies viruses collected from animal rabies cases between 2018 and 2022 were obtained. The phylogenetic and spatial-temporal evolutionary analyses showed that rabies viruses in the Philippines were exclusively classified into the SEA4 subclade within the Asian clade, but forming three major geographically specific lineages. Intra-island spread predominates the rabies transmission in three major island regions, while the inter-island transmission, between major island regions, is very limited, likely due to ocean barriers. Overall, our findings have provided the most comprehensive dataset on the infected animal species, geographic distribution, transmission dynamics, genetic diversity of rabies viruses, and transmission risk factors, thus established a basis to support WOAH-endorsed national control program for dog-mediated rabies in the Philippines.

Indexed as

RabiesRabies virusAnimalsDogsEvolution, MolecularPhilippinesPhylogenyPhylogeographymolecular epidemiologyPhilippinesrabies virusselection pressurestrategytransmission patterns

Identifiers

PMID39936582
PMCPMC11815495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.