ArticleInternational journal of immunopathology and pharmacology
Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling.
Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Melatonin is associated with cell-type-specific inflammatory and oxidative stress responses at the maternal-fetal interface.Frontiers in immunology · 2026Article
- Melatonin Modulates Astrocyte Inflammatory Response and Nrf2/SIRT1 Signaling Pathways in Adult Rat Cortical Cultures.Biomedicines · 2025Article
- Melatonin Ameliorates Desiccation Stress-Induced Ocular Inflammation in an In Vitro Model by Activating the Nrf2 Pathway.Journal of cellular and molecular medicine · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundOral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.
objectiveNovel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.
methodsThe impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells.
resultsMelatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated through the KEAP1/Nrf2 signaling pathway.
conclusionThese findings will contribute to the development of innovative therapies for inflammatory conditions affecting the oral epithelium.
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