Evidence map›Paper›PMID 39936497›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.

Hanwen Li, Yingchuang Tang, Sihan Hu, Xingbang Ruan, Junxin Zhang, Yihan Shi, Liang Qiu, Huilin Yang, Kai Zhang, Hao Chen and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. NJournal of orthopaedic translation · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hanwen LiDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Yingchuang TangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Sihan HuInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, 225000, P. R. China.
Xingbang RuanDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Junxin ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Yihan ShiDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Liang QiuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Huilin YangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Kai ZhangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Hao ChenInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, 225000, P. R. China.ORCID https://orcid.org/0000-0002-2622-2520
Kangwu ChenDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, P. R. China.

Funding

National Natural Science Foundation of China 82172468National Natural Science Foundation of China 82272542National Natural Science Foundation of China 82372436Natural Science Foundation for Training Program of the First Affiliated Hospital of Soochow University BXQN202220Natural Science Foundation of Jiangsu Province BK20220095Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX24_1815Suzhou Gusu Health Talent Plan talent research project GSWS2022009
6 · The paper itself

Abstract

Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1-related circRNA, is stably downregulated under abnormal stress. In vitro, circSMAD4 knockdown resulted in Yap1 mRNA degradation, whereas circSMAD4 overexpression increased Yap1 mRNA expression and nuclear translocation. Hence, the stabilization of circSMAD4 is essential for maintaining the homeostasis of endplate cartilage under abnormal stress. Furthermore, transcriptome sequencing and mass spectrometry analysis revealed that METTL14-mediated N

Indexed as

AdenosineIntervertebral Disc DegenerationLumbar VertebraeRNA, CircularAnimalsCartilageChondrocytesHumansMaleMiceMice, Inbred C57BLMice, KnockoutOsteogenesisYAP-Signaling ProteinsAdenosineN-methyladenosineRNA, CircularYap1 protein, mouseYAP-Signaling Proteinscartilage endplate ossificationcircSAMD4IGF2BP1lumbar instabilitym6A modificationYap1

Identifiers

PMID39936497
PMCPMC11967797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.