Evidence map›Paper›PMID 39936425›Full record

ArticleCurrent pharmaceutical design2025

Untargeted Metabolomics Analysis of Vaginal Secretion Reveals Potential Pathogenesis of Atrophic Vaginitis.

Chenyun Zhang, Yali Ren, Jiaxiong Li, Guanghua Wang, Jiehua Ma, Jin Qiu

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In one paragraph

Article in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenyun ZhangObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Yali RenWuxi School of Medicine, Jiangnan University, Shanghai, China.
Jiaxiong LiObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Guanghua WangObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Jiehua MaObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Jin QiuObstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.

Funding

Changning District Healthcare Research Program CNKW2022Y12Changning District Medical Master's and Doctoral Innovation Talent Base RCJD2021S01National Natural Science Foundation of China 82271659Shanghai Tongren Hospital and Donghua University School of Biological and Medical Engineering Cross Cooperation Project 2023DHYGJC-YBB01
6 · The paper itself

Abstract

introductionAtrophic vaginitis (AV) is a common and frequently occurring disease, lacking effective curative measures. Exploring the mechanism of vaginal mucosal homeostasis from the perspective of metabolites has great research prospects.

methodsWe compared the metabolic profiles of vaginal secretions between AV patients and healthy individuals via liquid chromatography-tandem mass spectrometry (LC-MS/MS). We further explored effective and sensitive metabolites and metabolic pathways for senile vaginitis through bioinformatics analysis and experimental verification. Through untargeted metabolomics analysis, we screened 561 differential metabolites in two groups of vaginal secretion samples. These differential metabolites were mainly concentrated in fatty acids/carboxylic acids, glycerophospholipids, organic oxides, steroids, and their derivatives. They were mainly enriched in purine metabolism, diabetic cardiomyopathy generation, and choline metabolism pathways.

resultsThe receiver operating characteristic analysis showed the metabolites (e.g., guggulsterone, umbelliprenin, and inosinic acid) to have good discrimination ability for the AV group. In addition, we also explored the potential mechanism of action of umbelliprenin at the cellular level.

conclusionThis study is expected to provide a new perspective for understanding the relationship between metabolites and the pathogenesis of AV.

Indexed as

Atrophic VaginitisBodily SecretionsMetabolomeVaginaAgedCase-Control StudiesComputational BiologyFemaleHumansLiquid Chromatography-Mass SpectrometryMetabolic Networks and PathwaysMetabolomicsMiddle AgedTandem Mass SpectrometryAtrophic vaginitisestrogen therapyinflammationpathogenesis.untargeted metabolomicsvaginal secretion

Identifiers

PMID39936425

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.