ArticleCurrent neuropharmacology2025
Vitamin C Protects from Impairment of Memory Induced by E-Cigarette Aerosol Exposure.
Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionE-cigarettes (EC) have been shown to impair memory by disrupting the balance involving ROS and antioxidant enzymes, leading to oxidative stress. Vitamin C (VitC) is a strong antioxidant with cell protective efficacy and scavenges free radicals. The present study evaluated VitC for potential protective effects against EC-induced memory impairment in rat models.
methodsThe animals were exposed to EC for 2 hr/day, with a one-hour break in between, for five days per week over four weeks. Simultaneously, animals were administered Vitamin C at 100 mg/ kilogram/bw/day via oral gavage five days/week/for four weeks. After the treatment and exposure period concluded, spatial learning and memory were evaluated using the Radial Arms Water Maze. Furthermore, the oxidative stress biomarkers levels (GSSG, GSH, GSH/GSSG, TBARS, Catalase, and GPx) and brain-derived neurotrophic factor (BDNF) were measured in the hippocampus tissues.
resultsThe findings indicated that EC had a detrimental effect on the short-term and long-term memory of the animals (p < 0.05). Additionally, EC decreased the levels of GPx, SOD, GSH, the GSH/GSSG ratio, and BDNF (p < 0.05). Furthermore, the GSSG level was significantly elevated (p < 0.05) by EC. However, Vitamin C prevented impairment of memory and restored levels of biomarkers of oxidative stress and BDNF.
conclusionTo summarize, exposure to EC resulted in impairments of memory, both short-term and long-term. However, the administration of Vitamin C prevented these negative effects by its antioxidant properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.