ReviewCurrent neuropharmacology2025
Determining the Interaction in a Drug Combination using the Dose-based or Effect-based Method.
Review in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multifunctional and dual-targeting polymeric prodrug nanomicelles against tamoxifen-resistant breast cancer.Scientific reports · 2026Article
- The ratio of effect-based combination indexes can indicate nonapoptotic cell-death in a combined cancer therapy.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction in a drug combination can be assessed using either the Chou's or Jin's method. The combination index in the former (i.e., CI-C) is calculated based on doses, while the latter (i.e., CI-J) is based on effects. This perspective demonstrates a consistency between 1/CI-C and CI-J when applied to both released and simulated data. Thus, 1/CI-C and CI-J are functionally equivalent for evaluating the drug interaction. Combining these two indices is preferred: a consistency shows a reliable verdict, and an inconsistency indicates a requirement for further analyses. However, it has been observed that evaluating released data raises certain concerns.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.