Evidence map›Paper›PMID 39936355›Full record

ReviewFuture oncology (London, England)2025

DRP1: shedding light on the complex nexus of mitochondrial fission and breast cancer.

Li You, Min Wang, Xuexue Liu, Miao Song, Jiahong Zhou, Jia Feng, Jinbo Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li YouDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.ORCID 0009-0007-5187-5244
Min WangDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Xuexue LiuDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Miao SongDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Jiahong ZhouDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Jia FengDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Jinbo LiuDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University. Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases. Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is a global women's health concern, with ongoing research to address diagnostic and treatment challenges. Understanding the developmental mechanisms is vital for improved clinical prevention and treatment strategies. Mitochondria, undergo dynamic processes like fission and fusion, regulated by proteins like Dynamic-related protein 1 (DRP1). DRP1 plays a key role in mitochondrial fission, a process associated with BC development. This study aims to explore the impact of DRP1 on BC growth, assessing its potential as a therapeutic target. The findings could contribute to a better understanding of mitochondria-related molecular mechanisms in BC development and guide the identification of clinical drug targets.

Indexed as

Breast NeoplasmsDynaminsMitochondriaMitochondrial DynamicsAnimalsFemaleHumansDNM1L protein, humanDynaminsBreast cancerDRP1fissionfusionmitochondrial

Identifiers

PMID39936355
PMCPMC11845117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.