Evidence map›Paper›PMID 39936238›Full record

ArticleJournal of neurochemistry2025

Oxidative Stress Suppresses Trk Signaling While Stimulating JNK-Mediated Endocytosis and Cleavage of p75

Poshan V Pokharel, Aaron M Newchurch, Sunny C Overby, Cassidy A Spease, Isaac T Perkins, Lorelei G Darzi, Nabin Ghimire, Ahmed Lawan, Bradley R Kraemer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Poshan V PokharelFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Aaron M NewchurchFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Sunny C OverbyFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Cassidy A SpeaseFrom the Department of Biological Sciences, Eastern Kentucky University, Richmond, Kentucky, USA.
Isaac T PerkinsFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Lorelei G DarziFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Nabin GhimireFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Ahmed LawanFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.
Bradley R KraemerFrom the Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama, USA.ORCID 0000-0002-7453-6559

Funding

The Role of the p75 Neurotrophin Receptor in Dopaminergic Neurodegeneration Induced by Oxidative Stress.R15NS111413 · NINDS · UNIVERSITY OF ALABAMA IN HUNTSVILLE · PI KRAEMER, BRADLEY R · 2022 to 2022
$438k
NINDS NIH HHS 1R15NS111413-01A1NINDS NIH HHS R15 NS111413University of Alabama in Huntsville Summer Community of Scholars Program
6 · The paper itself

Abstract

The p75 Neurotrophin Receptor (p75

Indexed as

EndocytosisMAP Kinase Signaling SystemNeuroprotectionOxidative StressParkinson DiseaseReceptors, Nerve Growth FactorReceptor, trkAAnimalsHumansMiceNerve Tissue ProteinsReceptor, Nerve Growth FactorSignal TransductionNerve Tissue ProteinsNGFR protein, humanReceptor, Nerve Growth FactorReceptors, Nerve Growth FactorReceptor, trkA

Identifiers

PMID39936238
PMCPMC11998641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.