ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011-2018.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Impact of body roundness index on cognitive decline and cognitive impairment in middle-aged and older adults ≥ 45 years: mediating role of biological aging.Scientific reports · 2026Article
- Age at menopause and risk of sarcopenia in postmenopausal women: evidence from the China health and retirement longitudinal study.Reproductive health · 2026Article
- Longitudinal associations between internet access and cognitive decline in older adults.Scientific reports · 2026Article
- Association of sleep duration and quality with age at natural menopause: results from NHANES 2005-2018.BMC women's health · 2026Observational
- Sleep duration, depression, and cognitive function among older adults in China: A longitudinal cohort study.Preventive medicine reports · 2026Article
- The association between age at menopause and circadian syndrome: a study based on the UK Biobank.BMC public health · 2026Article
- Associations of oral contraceptives and hormone replacement therapy with incident dementia risk: a population-based cohort study.Translational psychiatry · 2026Article
- Cardiovascular-kidney-metabolic syndrome stages 0-3 and cognitive decline in Chinese adults: a longitudinal analysis from the China health and retirement longitudinal study.BMC cardiovascular disorders · 2026Article
- Age at natural menopause and cognitive aging in U.S. women: Educational attainment as a modifiable resilience factor.Maturitas · 2026Article
- Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies.Frontiers in aging neuroscience · 2026Review
- Chronological age is differentially associated with cognitive performance according to climacteric stage: evidence from a Bayesian multivariate analysis in Chilean women.Frontiers in psychology · 2026Article
- Urban-rural differences and bidirectional association between social participation and cognitive function among Chinese older adults: a 10-year prospective cohort study.Archives of public health = Archives belges de sante publique · 2025Article
- Edentulism as an independent risk factor for sarcopenia: evidence from cross-sectional and longitudinal analyses based on the CHARLS cohort.BMC oral health · 2025Article
- Article
- Biological and social reproductive factors and late-life cognitive function in middle-aged and older Chinese women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Special Issue: "New Trends in Alzheimer's Disease Research: From Molecular Mechanisms to Therapeutics: 2nd Edition".International journal of molecular sciences · 2025Article
- Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011-2018.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association between triglyceride-glucose and triglyceride-glucose related indices with all-cause mortality in depression participants: a cohort study from NHANES.Frontiers in psychiatry · 2025Article
- Cognitive function changes and DTI-ALPS index in postmenopausal women.Frontiers in aging neuroscience · 2025Article
- Navigating midlife: Priorities and program needs of women in British Columbia.Women's health (London, England)Article
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Abstract
introductionChinese women experience higher dementia rates than men, yet sex-specific risk factors are understudied. We examined how menopause age affects cognitive function and decline in aging Chinese women.
methodsData were from 7419 postmenopausal women 45-101 years of age at baseline in the China Health and Retirement Longitudinal Study (CHARLS; 2011-2018). Menopause age was categorized using clinical cutoffs (<40, 40-44, 45-49, 50-55, >55 years). Cognitive function was assessed with neuropsychological tests up to four times over 7 years, and associations were analyzed using multivariable-adjusted linear mixed-effects regression.
resultsCompared to menopause at 50-55 years (3661/7419; 49.3%), premature (<40; 235/7419; 3.2%), early (40-44; 623/7419; 8.4%), and late menopause (>55; 366/7419; 4.9%) were associated with lower baseline cognitive scores. Although the rate of cognitive decline did not differ significantly across menopause age groups, late menopause showed a trend toward faster decline. DISCUSSION: Cognitive health interventions should consider extreme menopausal age as a risk factor. HIGHLIGHTS: Extreme menopausal ages-premature (<40), early (40-44), and late (>55)-are linked to lower baseline cognition versus menopause ages 50-55, persisting over 7 years. Cognitive disadvantage for late menopause (>55) versus 50-55 tends to increase over time. Health interventions should consider extreme menopause ages in women's cognitive health.
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