Evidence map›Paper›PMID 39936180›Full record

ArticleInternational journal of environmental health research2025

Concentrations of blood styrene and neurobehavioral function among Gulf state residents in the U.S.

Giehae Choi, Diane S Rohlman, Richard K Kwok, Emily J Werder, Kaitlyn G Lawrence, Aaron Blair, Aubrey K Miller, W Braxton Jackson, Dale P Sandler, Lawrence S Engel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Giehae ChoiDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Diane S RohlmanOccupational and Environmental Health, University of Iowa, Iowa City, IA, USA.
Richard K KwokPopulation Studies and Genetics Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Gaithersburg, MD, USA.
Emily J WerderEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, USA.
Kaitlyn G LawrenceEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, USA.
Aaron BlairOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Aubrey K MillerOffice of the Director, NIEHS, NIH, Bethesda, MD, USA.
W Braxton JacksonSocial & Scientific Systems, Inc., a DLH Holding Company, Durham, NC, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, USA.
Lawrence S EngelDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Gulf Longitudinal Follow-up (GuLF) Worker StudyZIAES102945 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2010 to 2025
$15.3M
Intramural NIH HHS ZIA ES102945NIEHS NIH HHS P30 ES005605NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

objectivesTo investigate relationships between blood styrene concentrations and neurobehavioral function among US Gulf State residents.

methodsOur study includes 328 Gulf state residents enrolled in the Gulf Long-term Follow-up Study with data on blood styrene concentrations (2012-2013) and neurobehavioral test results (2014-2016, Behavioral Assessment and Research System and trail making test). We estimated the differences in test scores by blood styrene quartiles and explored effect measure modification by smoking.

resultsStyrene was detected in 77% of participants (median: 0.06 ng/ml). We observed only weak associations and no apparent dose-response relationships between styrene levels and performance on any neurobehavioral tests, although some associations were more prominent in males. For some neurobehavioral tests, we observed modestly stronger associations among participants with higher cotinine levels (>15 ng/mL).

conclusionWe found limited support for an association between low-level blood styrene concentration and neurobehavioral test performance, although some associations were stronger among smokers.

Indexed as

Environmental ExposureEnvironmental PollutantsStyreneAdultAgedFemaleHumansMaleMiddle AgedNeuropsychological TestsUnited StatesYoung AdultEnvironmental PollutantsStyreneBARSGuLF Studyneurobehavioral examsStyrene

Identifiers

PMID39936180
PMCPMC12339754

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.