ArticleMuscle & nerve2025
Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis.
Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Driving with Motor Neuron Disease: Disease-Specific Considerations, Multi-Domain Assessments and Support Strategies.Brain sciences · 2026Review
- Predictors of respiratory decline in neuromuscular disorders.Respiratory medicine · 2026Review
- Acoustic Features in ALS: Taking a Pause to Appreciate a Novel Remote Respiratory Monitoring Strategy.Muscle & nerve · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
INTRODUCTION/
aimsRespiratory failure from hypoventilation is the most common cause of death in amyotrophic lateral sclerosis (ALS). However, ALS care rarely assesses hypercapnia, a physiologic measure of hypoventilation. We investigated the prevalence and clinical significance of daytime hypercapnia measured by transcutaneous carbon dioxide (tcCO
methodsThis retrospective study included patients seen at two ALS clinics in the United States between 2012 and 2024 who had tcCO
resultsDaytime hypercapnia was present in 33/328 (10%) patients at baseline. Hypercapnia was associated with an increased rate of death (aHR 2.1, 95% CI 1.4-3.3). Orthopnea or dyspnea was 70% sensitive for hypercapnia (95% CI 51%-84%). Absolute value of MIP (|MIP|) < 60 cmH DISCUSSION: TcCO
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