Evidence map›Paper›PMID 39936146›Full record

ArticleNational science review2025

Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation.

Shunyi Lu, Yuqi Yang, Zhuorun Song, Jie Cao, Zhihui Han, Linfu Chen, Yunfei He, Jiayi Wang, Yun Teng, Zengli Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. A universal consuming endogenous HBioactive materials · 2027
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shunyi LuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Yuqi YangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
Zhuorun SongDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Jie CaoInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
Zhihui HanInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
Linfu ChenInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
Yunfei HeSoochow University Institues for Translational Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Jiayi WangDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Yun TengDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Zengli ZhangDepartment of Environmental Health School of Public Health, Soochow University, Suzhou 215123, China.
Jun ZouDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Jun GeDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Huilin YangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
Liang ChengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical OS samples through bioinformatic analyses and further validated the inhibition of mitochondrial autophagy in OS at the transcriptomic level. Based on this finding, we investigated the therapeutic potential of a dual functional metal nanoplatform (MnS

Indexed as

autophagyH2S gas therapyimmunotherapymetal nanoplatform, MnSxosteosarcoma

Identifiers

PMID39936146
PMCPMC11812574

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.