Evidence map›Paper›PMID 39936081›Full record

ArticleToxicon: X2025

Feasibility study: Varespladib protects CD-1 mice from lethal doses of whole bee (

James Hearth, Kaitlin Linne, Jerry Harrison, Hossein Zolfaghari, Matthew R Lewin

Abstract read
In one paragraph

Article in Toxicon: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James HearthUniversity of San Francisco, United States.
Kaitlin LinneUniversity of California, San Francisco, United States.
Jerry HarrisonOphirex, Inc, United States.
Hossein ZolfaghariRutgers New Jersey Medical School, United States.
Matthew R LewinOphirex, Inc, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swarming Hymenoptera attacks can deliver high cumulative doses of venom resulting in death and life-threatening or chronically disabling injuries. Varespladib, a potent inhibitor of snake venom secretory PLA2 (sPLA2), is a relatively weak inhibitor of whole bee venom sPLA2

Indexed as

Bee stingHymenopteraPhospholipaseVarespladib

Identifiers

PMID39936081
PMCPMC11808668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.