Strategic Management of Descemet's Membrane Perforation During DALK in Advanced Keratoconus.

Objective: To report on the surgical treatment of advanced keratoconus (KC) with stromal scarring in a young male patient with asymmetric disease progression complicated by an intraoperative microperforation of Descemet's membrane (DM) during deep anterior lamellar keratoplasty (DALK). Methods: The surgical approach consisted of manual descemetic DALK (dDALK), further complicated with DM microperforation. Anterior segment ocular coherence tomography (AS-OCT) was used intraoperatively to locate the site and size of the tear. The surgeon decided not to convert to penetrating keratoplasty (PK), despite stromal scarring, significant ectasia, and variable corneal thickness, but rather to continue the dissection of the stromal bed with maximum precaution. Results: Postoperatively, visual results improved and reached the best corrected visual acuity of 20/20. Choosing a proper graft dimension and reaching anatomical separation up to the DM were the keys to obtaining such a positive refractive outcome. Discussions: DALK, the most advanced treatment for KC, was chosen as the ideal option for this young patient due to its advantages over PK: reduced rejection risk, fewer complications, quicker steroid tapering, and faster recovery. However, its steep learning curve remains a challenge for surgeons. Conclusions: Despite manual DALK being a more challenging and time-consuming procedure than PK, careful dissection of the stromal bed and diligent assessment of the affected DM can provide a better and safer outcome for selected patients. Even if initial postoperative visual results are impressive, the surgeon must pay attention to the patient's future check-ups to swiftly correct any possible complications.