ArticleFrontiers in surgery2025
Mendelian randomization analysis reveals causal relationship between tonsillectomy and irritable bowel syndrome.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study used two sample Mendelian randomization (MR) method to evaluate the causal relationship between tonsillectomy and irritable bowel syndrome (IBS). Methods: We selected tonsillectomy as the exposure factor and IBS as the outcome variable, using GWAS data from the IEU Open GWAS project. Instrumental variables (IVs) were SNPs strongly correlated and independent of tonsillectomy. MR-PRESSO was used for outlier removal. IVW was the primary MR analysis method, supplemented by MR-Egger regression, WM, WME, and simple mode. Cochran's Results: The IVW analysis indicated a positive association between genetically predicted tonsillectomy and IBS (OR = 1.682, 95% CI: 1.157-2.446, Conclusion: Genetics predicts a positive causal relationship between tonsillectomy and IBS, suggesting that prevention of IBS in tonsillectomy patients should be enhanced.
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