Evidence map›Paper›PMID 39935958›Full record

ArticleACS applied nano materials2024

Choline Carboxylic Acid Ionic Liquid-stabilized Anisotropic Gold Nanoparticles for Photothermal Therapy.

Priyavrat Vashisth, Cameron L Smith, Dhanush L Amarasekara, Gaya S Dasanyake, Gagandeep Singh, Claylee M Chism, Christine M Hamadani, Tanveer Shaikh, Noah Grovich, Briana Gamboa and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Priyavrat VashisthDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Cameron L SmithDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Dhanush L AmarasekaraDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Gaya S DasanyakeDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Gagandeep SinghDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Claylee M ChismDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Christine M HamadaniDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Tanveer ShaikhDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Noah GrovichDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Briana GamboaDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Nathan I HammerDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
Eden E L TannerDepartment of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR01AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2018 to 2022
$1.8M
The Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR56AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2024 to 2024
$417k
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NIAID NIH HHS R01 AI139479NIAID NIH HHS R56 AI139479NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) are commonly used in cancer research due to their unique physical and optical properties. However, current AuNP synthesis methods often involve cytotoxic cationic surfactants like cetyltrimethyl ammonium bromide (CTAB). Tedious CTAB replacement methodologies have been used to increase the biocompatibility, further increasing the complexity of synthesizing biocompatible AuNPs limiting their biomedical applications. To address this issue, we explore cholinium decanoate (CADA) ionic liquid (IL) as a biocompatible stabilizing agent by replacing CTAB using a simple modified seeded method for synthesizing anisotropic AuNPs for photothermal therapy of triple-negative breast cancer cells (MDA-MB-231). The prepared CADA AuNPs showed quasi-spherical morphology, confirmed by transmission electron microscopy (TEM) and a broad plasmonic absorption band using Vis-NIR spectroscopy. CADA AuNPs exhibited excellent in-vitro biocompatibility with both MCF-10A (healthy human mammary cells) and MDA-MB-231 cells. We evaluate their in-vitro photothermal efficacy against MDA-MB-231 cancer cells, demonstrating significant cell death even at low AuNP concentration (20 μg/mL), low laser power density (0.6 W/cm

Indexed as

biocompatibilitygold nanoparticlesionic liquidsphotothermal therapyplasmon resonanceseeded method

Identifiers

PMID39935958
PMCPMC11810124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.